TY - JOUR
T1 - Complex hypereosinophilia arising from post-polycythemia vera myelofibrosis
T2 - A case of imatinib-responsiveness
AU - Gentzler, Ryan D.
AU - Minella, Alex C.
AU - Stein, Brady L.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - The classical myeloproliferative neoplasms (MPNs) feature an overproduction of mature blood elements. Phenotypic conversion, including transformation to myelofibrosis (MF) in those with antecedent ET and PV is a feared complication. Hypereosinophilic syndromes (HESs), especially those with myeloproliferative variants, can display similar features, including organomegaly, marrow fibrosis, clonality, thrombotic tendencies, and acute myeloid leukemia (AML) transformation. However, this group of illnesses is typically clinically and molecularly distinct from the classical MPNs. We report a case of a 59-yr-old woman with complex hypereosinophilia in the setting of post-polycythemic myelofibrosis (post-PVMF), with multi-system end-organ damage characteristic of HES.
AB - The classical myeloproliferative neoplasms (MPNs) feature an overproduction of mature blood elements. Phenotypic conversion, including transformation to myelofibrosis (MF) in those with antecedent ET and PV is a feared complication. Hypereosinophilic syndromes (HESs), especially those with myeloproliferative variants, can display similar features, including organomegaly, marrow fibrosis, clonality, thrombotic tendencies, and acute myeloid leukemia (AML) transformation. However, this group of illnesses is typically clinically and molecularly distinct from the classical MPNs. We report a case of a 59-yr-old woman with complex hypereosinophilia in the setting of post-polycythemic myelofibrosis (post-PVMF), with multi-system end-organ damage characteristic of HES.
KW - Hypereosinophilia syndrome
KW - Imatinib
KW - Myelofibrosis
KW - Myeloproliferative disorder
KW - Polycythemia vera
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U2 - 10.1016/j.lrr.2012.07.001
DO - 10.1016/j.lrr.2012.07.001
M3 - Article
C2 - 24371761
AN - SCOPUS:84873323324
SN - 2213-0489
VL - 1
SP - 9
EP - 12
JO - Leukemia Research Reports
JF - Leukemia Research Reports
IS - 1
ER -