Complex rearrangement of the T cell receptor in large granular lymphocytosis associated with myeloid suppression

Leonidas C. Platanias; Richard A. Larson; James W. Vardiman; Herbert Reisel; Harvey M. Golomb; Timothy W. McKeithan

Complex rearrangement of the T cell receptor in large granular lymphocytosis associated with myeloid suppression

Leonidas C. Platanias^*, Richard A. Larson, James W. Vardiman, Herbert Reisel, Harvey M. Golomb, Timothy W. McKeithan

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A patient is described with neutropenia associated with large granular lymphocyte proliferation, whose peripheral blood cells were analyzed with the β chain gene probe of the T cell receptor (TCR). The pattern of rearrangement of the TCR was unusually complex, and apparently involved rearrangement of both Jβ1 loci with upstream Vβ segments and of both Jβ2 loci with a downstream Vβ by inversion. This case represents a unique pattern of rearrangement of the β-chain of TCR. These results suggest caution in estimating the number of clones present in apparent oligoclonal proliferations.

Original language	English (US)
Pages (from-to)	863-865
Number of pages	3
Journal	Leukemia
Volume	4
Issue number	12
State	Published - Dec 1990

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{1336887f05d14031bd6b3aeb4c3bb730,

title = "Complex rearrangement of the T cell receptor in large granular lymphocytosis associated with myeloid suppression",

abstract = "A patient is described with neutropenia associated with large granular lymphocyte proliferation, whose peripheral blood cells were analyzed with the β chain gene probe of the T cell receptor (TCR). The pattern of rearrangement of the TCR was unusually complex, and apparently involved rearrangement of both Jβ1 loci with upstream Vβ segments and of both Jβ2 loci with a downstream Vβ by inversion. This case represents a unique pattern of rearrangement of the β-chain of TCR. These results suggest caution in estimating the number of clones present in apparent oligoclonal proliferations.",

author = "Platanias, {Leonidas C.} and Larson, {Richard A.} and Vardiman, {James W.} and Herbert Reisel and Golomb, {Harvey M.} and McKeithan, {Timothy W.}",

year = "1990",

month = dec,

language = "English (US)",

volume = "4",

pages = "863--865",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Nature Publishing Group",

number = "12",

}

TY - JOUR

T1 - Complex rearrangement of the T cell receptor in large granular lymphocytosis associated with myeloid suppression

AU - Platanias, Leonidas C.

AU - Larson, Richard A.

AU - Vardiman, James W.

AU - Reisel, Herbert

AU - Golomb, Harvey M.

AU - McKeithan, Timothy W.

PY - 1990/12

Y1 - 1990/12

N2 - A patient is described with neutropenia associated with large granular lymphocyte proliferation, whose peripheral blood cells were analyzed with the β chain gene probe of the T cell receptor (TCR). The pattern of rearrangement of the TCR was unusually complex, and apparently involved rearrangement of both Jβ1 loci with upstream Vβ segments and of both Jβ2 loci with a downstream Vβ by inversion. This case represents a unique pattern of rearrangement of the β-chain of TCR. These results suggest caution in estimating the number of clones present in apparent oligoclonal proliferations.

AB - A patient is described with neutropenia associated with large granular lymphocyte proliferation, whose peripheral blood cells were analyzed with the β chain gene probe of the T cell receptor (TCR). The pattern of rearrangement of the TCR was unusually complex, and apparently involved rearrangement of both Jβ1 loci with upstream Vβ segments and of both Jβ2 loci with a downstream Vβ by inversion. This case represents a unique pattern of rearrangement of the β-chain of TCR. These results suggest caution in estimating the number of clones present in apparent oligoclonal proliferations.

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UR - http://www.scopus.com/inward/citedby.url?scp=0025649903&partnerID=8YFLogxK

M3 - Article

C2 - 2173805

AN - SCOPUS:0025649903

SN - 0887-6924

VL - 4

SP - 863

EP - 865

JO - Leukemia

JF - Leukemia

IS - 12

ER -

Complex rearrangement of the T cell receptor in large granular lymphocytosis associated with myeloid suppression

Abstract

ASJC Scopus subject areas

UN SDGs

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