A patient is described with neutropenia associated with large granular lymphocyte proliferation, whose peripheral blood cells were analyzed with the β chain gene probe of the T cell receptor (TCR). The pattern of rearrangement of the TCR was unusually complex, and apparently involved rearrangement of both Jβ1 loci with upstream Vβ segments and of both Jβ2 loci with a downstream Vβ by inversion. This case represents a unique pattern of rearrangement of the β-chain of TCR. These results suggest caution in estimating the number of clones present in apparent oligoclonal proliferations.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Dec 1990|
ASJC Scopus subject areas
- Cancer Research