Complex rearrangement of the T cell receptor in large granular lymphocytosis associated with myeloid suppression

Leonidas C. Platanias*, Richard A. Larson, James W. Vardiman, Herbert Reisel, Harvey M. Golomb, Timothy W. McKeithan

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

A patient is described with neutropenia associated with large granular lymphocyte proliferation, whose peripheral blood cells were analyzed with the β chain gene probe of the T cell receptor (TCR). The pattern of rearrangement of the TCR was unusually complex, and apparently involved rearrangement of both Jβ1 loci with upstream Vβ segments and of both Jβ2 loci with a downstream Vβ by inversion. This case represents a unique pattern of rearrangement of the β-chain of TCR. These results suggest caution in estimating the number of clones present in apparent oligoclonal proliferations.

Original languageEnglish (US)
Pages (from-to)863-865
Number of pages3
JournalLeukemia
Volume4
Issue number12
StatePublished - Dec 1990

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Platanias, L. C., Larson, R. A., Vardiman, J. W., Reisel, H., Golomb, H. M., & McKeithan, T. W. (1990). Complex rearrangement of the T cell receptor in large granular lymphocytosis associated with myeloid suppression. Leukemia, 4(12), 863-865.