@article{a1e4a9897a57492ebcb00edcba46cd45,
title = "Complications and Their Resolution in Recipients of Deceased and Living Donor Liver Transplants: Findings from the A2ALL Cohort Study",
abstract = "The purpose of this study was to explore long-term complications in recipients of deceased donor liver transplant (DDLT) and living donor liver transplant (LDLT) in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL). We analyzed 471 DDLTs and 565 LDLTs from 1998 to 2010 that were followed up to 10 years for 36 categories of complications. Probabilities of complications and their resolutions were estimated using the Kaplan-Meier method, and predictors were tested in Cox proportional hazards models. Median follow-up for DDLT and LDLT was 4.19 and 4.80 years, respectively. DDLT recipients were more likely to have hepatocellular carcinoma and higher disease severity, including Model for End-Stage Liver Disease score. Complications occurring with higher probability in LDLT included biliary-related complications and hepatic artery thrombosis. In DDLT, ascites, intra-abdominal bleeding, cardiac complications and pulmonary edema were significantly more probable. Development of chronic kidney disease stage 4 or 5 was less likely in LDLT recipients (hazard ratio [HR] 0.41, p = 0.02). DDLT and LDLT had similar risk of grade 4 complications (HR 0.89, p = 0.60), adjusted for other risk factors. Once a complication occurred, the time to resolution did not differ between LDLT and DDLT. Future efforts should be directed toward reducing the occurrence of complications after liver transplantation.",
author = "Benjamin Samstein and Smith, {A. R.} and Freise, {C. E.} and Zimmerman, {M. A.} and T. Baker and Olthoff, {K. M.} and Fisher, {R. A.} and Merion, {R. M.}",
note = "Funding Information: This study was supported by the National Institute of Diabetes and Digestive and Kidney Diseases through cooperative agreements (grants U01- DK62444, U01-DK62467, U01-DK62483, U01-DK62484, U01-DK62494, U01-DK62496, U01-DK62498, U01-DK62505, U01-DK62531, and U01- DK62536). Additional support was provided by the Health Resources and Services Administration and the American Society of Transplant Surgeons. The supplemental data reported have been supplied by the Minneapolis Medical Research Foundation as the contractor for the Scientific Registry of Transplant Recipients (SRTR). The interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as an official policy of or interpretation by the SRTR or the US government. This paper is publication number 28 of the Adult-to-Adult Living Donor Liver Transplantation Cohort Study. The following individuals were instrumental in the planning and conduct of this study at each of the participating institutions: Columbia University Medical Center, NewYork, NY (DK62483): PI: Jean C. Emond, MD; Co-Is: Robert S. Brown, Jr., MD,MPH, James Guarrera, MD, FACS, Martin R. Prince, MD, PhD, Benjamin Samstein, MD, Elizabeth Verna, MD, MS; Study Coordinators: Taruna Chawla, MD, Scott Heese, MPH, Theresa Lukose, PharmD, Rudina Odeh-Ramadan, PharmD, Jonah Zaretsky, BS. Northwestern University, Chicago, IL (DK62467): PI: Michael M.I. Abecassis, MD, MBA; Co-Is: Talia Baker, MD, Laura M. Kulik, MD, Daniela P. Ladner,MD; Study Coordinator: Patrice Al-Saden, RN, CCRC. University of California Los Angeles, Los Angeles, CA (DK62496): PI: Johnny C. Hong, MD; Co-I: Ronald W. Busuttil, MD, PhD; Study Coordinator: Janet Mooney, RN, BSN. University of California San Francisco, San Francisco, CA (DK62444): PI: Chris E. Freise, MD, FACS; Co-I: Norah A. Terrault, MD, MPH; Study Coordinator: Dulce MacLeod, RN. University of Colorado Denver, Aurora, CO (DK62536): PI: James R. Burton, Jr., MD; Co-Is: Gregory T. Everson, MD, FACP, Igal Kam, MD, James Trotter, MD; Study Coordinators: Carlos Garcia, RN, BS, Anastasia Krajec, RN. University of Michigan Health System, Ann Arbor, MI (DK62498): PI: Robert M. Merion, MD, FACS; DCC Staff: Mary Akagi, MS, CCRP, Douglas R. Armstrong, BSN, MS, Abby Brithinee, BA, Margaret Hill- Callahan, BS, LSW, Lisa Holloway, BS, CCRC, Terese A. Howell, BS, CCRC, Brenda W. Gillespie, PhD, Beth Golden, BScN, Anna S.F. Lok, MD, Monique Lowe, MSI, Akinlolu O. Ojo, MD, PhD, Samia Shaw, AAIT, Abigail Smith, MS, Robert A. Wolfe, PhD. University of North Carolina, Chapel Hill, NC (DK62505): PI: Paul H. Hayashi, MD, MPH; Study Coordinator: Tracy Russell, MA. University of Pennsylvania, Philadelphia, PA (DK62494): PI: Abraham Shaked,MD, PhD; Co-Is: KimM. Olthoff,MD, FACS, K. Rajender Reddy, MD,MarkA.Rosen,MD,PhD;StudyCoordinators:BrianConboy,PA,MBA, Mary Kaminski, PA-C, DebraMcCorriston, RN,Mary Shaw, RN, BBA. University of Virginia (DK62484): PI: Carl L. Berg, MD; Co-I: Timothy L. Pruett, MD; Study Coordinator: Jaye Davis, RN. Virginia Commonwealth University - Medical College of Virginia, Richmond, VA (DK62531): PI: Robert A. Fisher, MD, FACS; Co-Is: Adrian Cotterell,MD,FACS,R.ToddStravitz,MD,FACP;StudyCoordinators:April Ashworth, RN, BSN, Joanne Davis,RN, Ede Fenick,RN, Andrea Lassiter, BS, Cheryl Rodgers, RN, Jose Rodriguez,MPH, Luke Wolfe, MS. National Institute of Diabetes and Digestive and Kidney Diseases, Division of Digestive Diseases and Nutrition, Bethesda, MD: Edward Doo, MD, James E. Everhart, MD, MPH, Jay H. Hoofnagle, MD, Stephen James, MD, Patricia R. Robuck, PhD, Leonard B. Seeff, MD, Rebecca J. Torrance, RN, MS. Publisher Copyright: Copyright {\textcopyright} 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.",
year = "2016",
month = feb,
day = "1",
doi = "10.1111/ajt.13479",
language = "English (US)",
volume = "16",
pages = "594--602",
journal = "American Journal of Transplantation",
issn = "1600-6135",
publisher = "Wiley-Blackwell",
number = "2",
}