Complications associated with bone morphogenetic protein in the lumbar spine

Daniel G. Kang*, Wellington K. Hsu, Ronald A. Lehman

*Corresponding author for this work

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Complications associated with the use of recombinant human bone morphogenetic protein in the lumbar spine include retrograde ejaculation, ectopic bone formation, vertebral osteolysis and subsidence, postoperative radiculitis, and hematoma and seroma. These complications are controversial and remain widely debated. This article discusses the reported complications and possible implications for the practicing spine surgeon. Understanding the complications associated with the use of recombinant human bone morphogenetic protein and the associated controversies allows for informed decision making by both the patient and the surgeon.

Original languageEnglish (US)
Pages (from-to)e229-e237
JournalOrthopedics
Volume40
Issue number2
DOIs
StatePublished - Mar 1 2017

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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