Comprehensive description of light scattering by simultaneous measurement of angular, spectral, and polarization dependence for characterization of tissue microarchitecture in normal and precancerous states

Young L. Kim*, Yang Liu, Ramesh K. Wali, Hemant K. Roy, Michael J. Goldberg, Alexey K. Kromin, Kun Chen, Vadim Backman

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations

Abstract

The most comprehensive description of light scattering was obtained by simultaneous measurement of its spectral, angular, azimuthal, and polarization characteristics. In studies with physical tissue models consisting of aqueous suspensions of microspheres, we showed that this comprehensive information reveals the properties of the internal structure of the samples. In the studies with a rodent model of colon carcinogenesis, we demonstrated the feasibility of detecting slight alterations of tissue micro-architecture by recording the multi-dimensional data characterizing tissue light scattering. We showed for the first time that such light scattering "fingerprinting" can be used to detect changes in tissue micro-architecture even at the earliest pre-dysplastic stages of carcinogenesis, much earlier than currently known histological, molecular, or genetic markers.

Original languageEnglish (US)
Pages (from-to)95-105
Number of pages11
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5141
StatePublished - Dec 1 2003
EventDiagnostic Optical Spectroscopy in Biomedicine II - Munich, Germany
Duration: Jun 24 2003Jun 25 2003

Keywords

  • Early cancer detection
  • Elastic light scattering
  • Light scattering spectroscopy
  • Mie theory
  • Polarization gating

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'Comprehensive description of light scattering by simultaneous measurement of angular, spectral, and polarization dependence for characterization of tissue microarchitecture in normal and precancerous states'. Together they form a unique fingerprint.

Cite this