Abstract
The most comprehensive description of light scattering was obtained by simultaneous measurement of its spectral, angular, azimuthal, and polarization characteristics. In studies with physical tissue models consisting of aqueous suspensions of microspheres, we showed that this comprehensive information reveals the properties of the internal structure of the samples. In the studies with a rodent model of colon carcinogenesis, we demonstrated the feasibility of detecting slight alterations of tissue micro-architecture by recording the multi-dimensional data characterizing tissue light scattering. We showed for the first time that such light scattering "fingerprinting" can be used to detect changes in tissue micro-architecture even at the earliest pre-dysplastic stages of carcinogenesis, much earlier than currently known histological, molecular, or genetic markers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 95-105 |
| Number of pages | 11 |
| Journal | Proceedings of SPIE - The International Society for Optical Engineering |
| Volume | 5141 |
| State | Published - 2003 |
| Event | Diagnostic Optical Spectroscopy in Biomedicine II - Munich, Germany Duration: Jun 24 2003 → Jun 25 2003 |
Keywords
- Early cancer detection
- Elastic light scattering
- Light scattering spectroscopy
- Mie theory
- Polarization gating
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Computer Science Applications
- Applied Mathematics
- Electrical and Electronic Engineering
