Comprehensive echocardiographic evaluation of the right heart in patients with pulmonary vascular diseases: the PVDOMICS experience

Christine L. Jellis; Margaret M. Park; Aiden Abidov; Barry A. Borlaug; Evan L. Brittain; Robert Frantz; Paul M. Hassoun; Evelyn M. Horn; Wael A. Jaber; Kim Jiwon; Maria G. Karas; Deborah Kwon; Jane A. Leopold; Bradley Maron; Stephen C. Mathai; Reena Mehra; Franz Rischard; Erika B. Rosenzweig; W. H.Wilson Tang; Rebecca Vanderpool; James D. Thomas

doi:10.1093/ehjci/jeab065

Comprehensive echocardiographic evaluation of the right heart in patients with pulmonary vascular diseases: the PVDOMICS experience

Christine L. Jellis^*, Margaret M. Park, Aiden Abidov, Barry A. Borlaug, Evan L. Brittain, Robert Frantz, Paul M. Hassoun, Evelyn M. Horn, Wael A. Jaber, Kim Jiwon, Maria G. Karas, Deborah Kwon, Jane A. Leopold, Bradley Maron, Stephen C. Mathai, Reena Mehra, Franz Rischard, Erika B. Rosenzweig, W. H.Wilson Tang, Rebecca VanderpoolJames D. Thomas

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Aims: There is a wide spectrum of diseases associated with pulmonary hypertension, pulmonary vascular remodelling, and right ventricular dysfunction. The NIH-sponsored PVDOMICS network seeks to perform comprehensive clinical phenotyping and endophenotyping across these disorders to further evaluate and define pulmonary vascular disease. Methods and results: Echocardiography represents the primary non-invasive method to phenotype cardiac anatomy, function, and haemodynamics in these complex patients. However, comprehensive right heart evaluation requires the use of multiple echocardiographic parameters and optimized techniques to ensure optimal image acquisition. The PVDOMICS echo protocol outlines the best practice approach to echo phenotypic assessment of the right heart/pulmonary artery unit. Conclusion: Novel workflow processes, methods for quality control, data for feasibility of measurements, and reproducibility of right heart parameters derived from this study provide a benchmark frame of reference. Lessons learned from this protocol will serve as a best practice guide for echocardiographic image acquisition and analysis across the spectrum of right heart/pulmonary vascular disease.

Original language	English (US)
Pages (from-to)	958-969
Number of pages	12
Journal	European heart journal cardiovascular Imaging
Volume	23
Issue number	7
DOIs	https://doi.org/10.1093/ehjci/jeab065
State	Published - Jul 1 2022

Funding

The study received grants from the National Heart, Lung and Blood Institute: U01 HL125218, U01 HL125205, U01 HL125212, U01 HL125208, U01 HL125175, U01 HL125215, and U01 HL125177, and funding from the Pulmonary Hypertension Association.

Keywords

TAPSE
echocardiography
fractional area change
pulmonary hypertension
right ventricle
strain

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ehjci/jeab065

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Jellis, C. L., Park, M. M., Abidov, A., Borlaug, B. A., Brittain, E. L., Frantz, R., Hassoun, P. M., Horn, E. M., Jaber, W. A., Jiwon, K., Karas, M. G., Kwon, D., Leopold, J. A., Maron, B., Mathai, S. C., Mehra, R., Rischard, F., Rosenzweig, E. B., Tang, W. H. W., ... Thomas, J. D. (2022). Comprehensive echocardiographic evaluation of the right heart in patients with pulmonary vascular diseases: the PVDOMICS experience. European heart journal cardiovascular Imaging, 23(7), 958-969. https://doi.org/10.1093/ehjci/jeab065

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title = "Comprehensive echocardiographic evaluation of the right heart in patients with pulmonary vascular diseases: the PVDOMICS experience",

abstract = "Aims: There is a wide spectrum of diseases associated with pulmonary hypertension, pulmonary vascular remodelling, and right ventricular dysfunction. The NIH-sponsored PVDOMICS network seeks to perform comprehensive clinical phenotyping and endophenotyping across these disorders to further evaluate and define pulmonary vascular disease. Methods and results: Echocardiography represents the primary non-invasive method to phenotype cardiac anatomy, function, and haemodynamics in these complex patients. However, comprehensive right heart evaluation requires the use of multiple echocardiographic parameters and optimized techniques to ensure optimal image acquisition. The PVDOMICS echo protocol outlines the best practice approach to echo phenotypic assessment of the right heart/pulmonary artery unit. Conclusion: Novel workflow processes, methods for quality control, data for feasibility of measurements, and reproducibility of right heart parameters derived from this study provide a benchmark frame of reference. Lessons learned from this protocol will serve as a best practice guide for echocardiographic image acquisition and analysis across the spectrum of right heart/pulmonary vascular disease.",

keywords = "TAPSE, echocardiography, fractional area change, pulmonary hypertension, right ventricle, strain",

author = "Jellis, {Christine L.} and Park, {Margaret M.} and Aiden Abidov and Borlaug, {Barry A.} and Brittain, {Evan L.} and Robert Frantz and Hassoun, {Paul M.} and Horn, {Evelyn M.} and Jaber, {Wael A.} and Kim Jiwon and Karas, {Maria G.} and Deborah Kwon and Leopold, {Jane A.} and Bradley Maron and Mathai, {Stephen C.} and Reena Mehra and Franz Rischard and Rosenzweig, {Erika B.} and Tang, {W. H.Wilson} and Rebecca Vanderpool and Thomas, {James D.}",

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doi = "10.1093/ehjci/jeab065",

language = "English (US)",

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Jellis, CL, Park, MM, Abidov, A, Borlaug, BA, Brittain, EL, Frantz, R, Hassoun, PM, Horn, EM, Jaber, WA, Jiwon, K, Karas, MG, Kwon, D, Leopold, JA, Maron, B, Mathai, SC, Mehra, R, Rischard, F, Rosenzweig, EB, Tang, WHW, Vanderpool, R & Thomas, JD 2022, 'Comprehensive echocardiographic evaluation of the right heart in patients with pulmonary vascular diseases: the PVDOMICS experience', European heart journal cardiovascular Imaging, vol. 23, no. 7, pp. 958-969. https://doi.org/10.1093/ehjci/jeab065

TY - JOUR

T1 - Comprehensive echocardiographic evaluation of the right heart in patients with pulmonary vascular diseases

T2 - the PVDOMICS experience

AU - Jellis, Christine L.

AU - Park, Margaret M.

AU - Abidov, Aiden

AU - Borlaug, Barry A.

AU - Brittain, Evan L.

AU - Frantz, Robert

AU - Hassoun, Paul M.

AU - Horn, Evelyn M.

AU - Jaber, Wael A.

AU - Jiwon, Kim

AU - Karas, Maria G.

AU - Kwon, Deborah

AU - Leopold, Jane A.

AU - Maron, Bradley

AU - Mathai, Stephen C.

AU - Mehra, Reena

AU - Rischard, Franz

AU - Rosenzweig, Erika B.

AU - Tang, W. H.Wilson

AU - Vanderpool, Rebecca

AU - Thomas, James D.

PY - 2022/7/1

Y1 - 2022/7/1

N2 - Aims: There is a wide spectrum of diseases associated with pulmonary hypertension, pulmonary vascular remodelling, and right ventricular dysfunction. The NIH-sponsored PVDOMICS network seeks to perform comprehensive clinical phenotyping and endophenotyping across these disorders to further evaluate and define pulmonary vascular disease. Methods and results: Echocardiography represents the primary non-invasive method to phenotype cardiac anatomy, function, and haemodynamics in these complex patients. However, comprehensive right heart evaluation requires the use of multiple echocardiographic parameters and optimized techniques to ensure optimal image acquisition. The PVDOMICS echo protocol outlines the best practice approach to echo phenotypic assessment of the right heart/pulmonary artery unit. Conclusion: Novel workflow processes, methods for quality control, data for feasibility of measurements, and reproducibility of right heart parameters derived from this study provide a benchmark frame of reference. Lessons learned from this protocol will serve as a best practice guide for echocardiographic image acquisition and analysis across the spectrum of right heart/pulmonary vascular disease.

AB - Aims: There is a wide spectrum of diseases associated with pulmonary hypertension, pulmonary vascular remodelling, and right ventricular dysfunction. The NIH-sponsored PVDOMICS network seeks to perform comprehensive clinical phenotyping and endophenotyping across these disorders to further evaluate and define pulmonary vascular disease. Methods and results: Echocardiography represents the primary non-invasive method to phenotype cardiac anatomy, function, and haemodynamics in these complex patients. However, comprehensive right heart evaluation requires the use of multiple echocardiographic parameters and optimized techniques to ensure optimal image acquisition. The PVDOMICS echo protocol outlines the best practice approach to echo phenotypic assessment of the right heart/pulmonary artery unit. Conclusion: Novel workflow processes, methods for quality control, data for feasibility of measurements, and reproducibility of right heart parameters derived from this study provide a benchmark frame of reference. Lessons learned from this protocol will serve as a best practice guide for echocardiographic image acquisition and analysis across the spectrum of right heart/pulmonary vascular disease.

KW - TAPSE

KW - echocardiography

KW - fractional area change

KW - pulmonary hypertension

KW - right ventricle

KW - strain

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DO - 10.1093/ehjci/jeab065

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AN - SCOPUS:85130682780

SN - 2047-2404

VL - 23

SP - 958

EP - 969

JO - European heart journal cardiovascular Imaging

JF - European heart journal cardiovascular Imaging

IS - 7

ER -

Comprehensive echocardiographic evaluation of the right heart in patients with pulmonary vascular diseases: the PVDOMICS experience

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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