Comprehensive fertility preservation can be offered in a timely manner around gonadotoxic therapy in children and adolescents

Kathryn L. McElhinney*, Samantha K. McLean, Sara Zarnegar-Lumley, Monica M. Laronda, Erin E. Rowell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Treatment for certain childhood cancers and nonmalignant conditions can lead to future infertility and gonadal failure. The risk of treatment delay must be considered when offering fertility preservation (FP) options. We examined the timeline from FP referral to return to treatment (RTT) in pediatric patients who underwent FP due to iatrogenic risk for infertility. Methods: A retrospective review was performed of patients with FP consultation due to an increased risk of iatrogenic infertility at Ann & Robert H. Lurie Children's Hospital of Chicago from 2018 to 2022. Data on diagnosis, age, treatment characteristics, and procedure were collected. Results: A total of 337 patients (n = 149 with ovaries, n = 188 with testes) had an FP consultation. Of patients with ovaries, 106 (71.1%) underwent ovarian tissue cryopreservation (OTC), 10 (6.7%) completed ovarian stimulation/egg retrieval (OSER), and 33 (22.1%) declined FP. Of the patients with testes, 98 (52.1%) underwent testicular tissue cryopreservation (TTC), 48 (25.5%) completed sperm banking (SB), and 42 (22.3%) declined FP. Median time from referral to FP consultation was short (ovaries: 2 days, range: 0–6; testes: 1 day, range: 0–5). OSER had a significantly longer RTT versus OTC and no FP (52.5 vs.19.5 vs. 12 days, p =.01). SB had a significantly quicker RTT compared to TTC or no FP (9.0 vs. 21.0 vs. 13.5 days; p =.008). For patients who underwent OTC/TTC and those who declined FP, there was no significant difference in time from consultation to treatment. Conclusions: It is feasible to promptly offer and complete FP with minimal delay to disease-directed treatment.

Original languageEnglish (US)
Article numbere31232
JournalPediatric Blood and Cancer
Volume71
Issue number10
DOIs
StatePublished - Oct 2024

Keywords

  • fertility preservation
  • ovarian tissue cryopreservation
  • pediatric cancer
  • pediatric oncofertility
  • testicular tissue cryopreservation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Fingerprint

Dive into the research topics of 'Comprehensive fertility preservation can be offered in a timely manner around gonadotoxic therapy in children and adolescents'. Together they form a unique fingerprint.

Cite this