TY - JOUR
T1 - Comprehensive pregnancy monitoring with a network of wireless, soft, and flexible sensors in high-and low-resource health settings
AU - Ryu, Dennis
AU - Kim, Dong Hyun
AU - Price, Joan T.
AU - Lee, Jong Yoon
AU - Chung, Ha Uk
AU - Allen, Emily
AU - Walter, Jessica R.
AU - Jeong, Hyoyoung
AU - Cao, Jingyue
AU - Kulikova, Elena
AU - Abu-Zayed, Hajar
AU - Lee, Rachel
AU - Martell, Knute L.
AU - Zhang, Michael
AU - Kampmeier, Brianna R.
AU - Hill, Marc
AU - Lee, Joo Hee
AU - Kim, Edward
AU - Park, Yerim
AU - Jang, Hokyung
AU - Arafa, Hany
AU - Liu, Claire
AU - Chisembele, Maureen
AU - Vwalika, Bellington
AU - Sindano, Ntazana
AU - Spelke, M. Bridget
AU - Paller, Amy S.
AU - Premkumar, Ashish
AU - Grobman, William A.
AU - Stringer, Jeffrey S.A.
AU - Rogers, John A.
AU - Xu, Shuai
N1 - Funding Information:
ACKNOWLEDGMENTS. S.X. and J.A.R. recognize support from the the Bill & Melinda Gates Foundation (OPP1193311 and INV-000787), Save the Children Foundation (award 999002170), and the NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development (1R41HD100284-01). S.X. and J.R.W. recognize support from the Health Resources and Services Administration’s Maternal and Child Health Bureau Grand Challenges in Remote Pregnancy Monitoring. J.T.P and J.S.A.S. recognize support from the Bill & Melinda Gates Foundation (OPP1192462 and INV001805).
Funding Information:
S.X. and J.A.R. recognize support from the the Bill & Melinda Gates Foundation (OPP1193311 and INV-000787), Save the Children Foundation (award 999002170), and the NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development (1R41HD100284- 01). S.X. and J.R.W. recognize support from the Health Resources and Services Administration's Maternal and Child Health Bureau Grand Challenges in Remote Pregnancy Monitoring. J.T.P and J.S.A.S. recognize support from the Bill & Melinda Gates Foundation (OPP1192462 and INV001805).
Publisher Copyright:
© 2021 National Academy of Sciences. All rights reserved.
PY - 2021/5/18
Y1 - 2021/5/18
N2 - Vital signs monitoring is a fundamental component of ensuring the health and safety of women and newborns during pregnancy, labor, and childbirth. This monitoring is often the first step in early detection of pregnancy abnormalities, providing an opportunity for prompt, effective intervention to prevent maternal and neonatal morbidity and mortality. Contemporary pregnancy monitoring systems require numerous devices wired to large base units; at least five separate devices with distinct user interfaces are commonly used to detect uterine contractility, maternal blood oxygenation, temperature, heart rate, blood pressure, and fetal heart rate. Current monitoring technologies are expensive and complex with implementation challenges in low-resource settings where maternal morbidity and mortality is the greatest. We present an integrated monitoring platform leveraging advanced flexible electronics, wireless connectivity, and compatibility with a wide range of low-cost mobile devices. Three flexible, soft, and low-profile sensors offer comprehensive vital signs monitoring for both women and fetuses with time-synchronized operation, including advanced parameters such as continuous cuffless blood pressure, electrohysterography-derived uterine monitoring, and automated body position classification. Successful field trials of pregnant women between 25 and 41 wk of gestation in both highresource settings (n = 91) and low-resource settings (n = 485) demonstrate the system's performance, usability, and safety.
AB - Vital signs monitoring is a fundamental component of ensuring the health and safety of women and newborns during pregnancy, labor, and childbirth. This monitoring is often the first step in early detection of pregnancy abnormalities, providing an opportunity for prompt, effective intervention to prevent maternal and neonatal morbidity and mortality. Contemporary pregnancy monitoring systems require numerous devices wired to large base units; at least five separate devices with distinct user interfaces are commonly used to detect uterine contractility, maternal blood oxygenation, temperature, heart rate, blood pressure, and fetal heart rate. Current monitoring technologies are expensive and complex with implementation challenges in low-resource settings where maternal morbidity and mortality is the greatest. We present an integrated monitoring platform leveraging advanced flexible electronics, wireless connectivity, and compatibility with a wide range of low-cost mobile devices. Three flexible, soft, and low-profile sensors offer comprehensive vital signs monitoring for both women and fetuses with time-synchronized operation, including advanced parameters such as continuous cuffless blood pressure, electrohysterography-derived uterine monitoring, and automated body position classification. Successful field trials of pregnant women between 25 and 41 wk of gestation in both highresource settings (n = 91) and low-resource settings (n = 485) demonstrate the system's performance, usability, and safety.
KW - Biosensors
KW - Pregnancy
KW - Vital signs
UR - http://www.scopus.com/inward/record.url?scp=85105772170&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85105772170&partnerID=8YFLogxK
U2 - 10.1073/pnas.2100466118
DO - 10.1073/pnas.2100466118
M3 - Article
C2 - 33972445
AN - SCOPUS:85105772170
VL - 118
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 20
M1 - e2100466118
ER -