Comprehensive Review on Colorectal Cancer and Transplant

S. Prenner, J. Levitsky*

*Corresponding author for this work

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Colorectal cancer (CRC) is a common malignancy worldwide. Some studies suggest that organ recipients are at a higher risk for CRC than the general population. The underlying transplant indications and their inherent risk factors for CRC may drive the variation in incidence rates that are seen in patients receiving different allografts. Recipients with cystic fibrosis are now recognized as a population at high risk for CRC at a young age. Transplant recipients have high mortality following a CRC diagnosis, even if it is detected at an early stage. Certain types of immunosuppression have been shown to accelerate cancer transformation and may contribute to the more aggressive phenotype seen in organ recipients. Given the high incidence and progressive nature of posttransplant CRC, shorter screening intervals with a modality that can detect early-stage polyps may be essential to prevent mortality. Future research is needed to better elucidate the role of immunosuppression in carcinogenesis. This comprehensive review examines CRC risk, screening, and management specific to organ transplant candidates and recipients.

Original languageEnglish (US)
Pages (from-to)2761-2774
Number of pages14
JournalAmerican Journal of Transplantation
Volume17
Issue number11
DOIs
StatePublished - Nov 2017

Keywords

  • cancer/malignancy/neoplasia: risk factors
  • clinical research/practice
  • complication: malignant
  • hematology/oncology
  • organ transplantation in general

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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