Computational modeling and simulation of complex systems in bio-electronics

Joseph W. Jerome, Bice Chini, Massimo Longaretti, Riccardo Sacco*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


In this article, we discuss the mathematical and computational framework required to develop a general-purpose simulation tool for bio-electronic applications. Electrochemical and fluid-mechanical transport of substances, chemical reactions and electrical transduction of biological signals are described through the coupled use of systems of partial and ordinary differential equations (PDEs and ODEs). Functional iteration techniques for system decoupling and mixed-hybridized finite element discretization methods are proposed and validated in the simulation of realistic problems in Electrophysiology and Biochemistry.

Original languageEnglish (US)
Pages (from-to)10-13
Number of pages4
JournalJournal of Computational Electronics
Issue number1
StatePublished - Mar 2008


  • Electrophysiology
  • Hybrid bio-artificial systems
  • Ionic channels
  • Ionic-electrical coupling
  • Mathematical modeling
  • Nanotechnology
  • Numerical simulation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Modeling and Simulation
  • Electrical and Electronic Engineering


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