Computational modeling evidence of a nonthermal electromagnetic interaction mechanism with living cells: Microwave nonlinearity in the cellular sodium ion channel

Nikolay S. Stoykov; Joseph W. Jerome; Lauren C. Pierce; Allen Taflove

doi:10.1109/TMTT.2004.831924

Computational modeling evidence of a nonthermal electromagnetic interaction mechanism with living cells: Microwave nonlinearity in the cellular sodium ion channel

Nikolay S. Stoykov^*, Joseph W. Jerome, Lauren C. Pierce, Allen Taflove

^*Corresponding author for this work

Mathematics

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A computational hydrodynamics model consisting of a system of four coupled time-domain partial differential equations is applied to study the response of the cellular sodium ion channel to a microwave electric-field excitation. The model employs a dynamic conservation law formulation, which has not been previously applied to this problem. Results indicate that the cellular sodium ion channel exhibits an electrical nonlinearity at microwave frequencies, which generates an intermodulation spectrum when excited by an amplitude-modulated electric field. Intermodulation products having frequencies down to 50 MHz, and very likely well below 50 MHz, appear possible. This is a new nonthermal microwave interaction mechanism with living tissues that, if observable below 0.1 MHz, could enable the stimulation of excitable biological tissues, and thereby have significant implications for human health and safety.

Original language	English (US)
Pages (from-to)	2040-2045
Number of pages	6
Journal	IEEE Transactions on Microwave Theory and Techniques
Volume	52
Issue number	8 II
DOIs	https://doi.org/10.1109/TMTT.2004.831924
State	Published - Aug 2004

Funding

Manuscript received July 8, 2003; revised February 13, 2004. This work was supported in part by the National Science Foundation under Grant DMS-0311263. N. S. Stoykov is with the Rehabilitation Institute of Chicago, Chicago, IL 60611 USA and also with the Department of Physical Medicine and Rehabilitation, Northwestern University, Chicago, IL 60611 USA (e-mail: [email protected]). J. W. Jerome is with the Department of Mathematics, Northwestern University, Evanston, IL 60208 USA. L. C. Pierce is with the Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL 60208 USA. A. Taflove is with the Department of Electrical and Computer Engineering, Northwestern University, Evanston, IL 60208 USA. Digital Object Identifier 10.1109/TMTT.2004.831924

Keywords

Computational modeling
Electromagnetic interactions
Living cells
Microwaves
Nonlinearity
Nonthermal

ASJC Scopus subject areas

Radiation
Condensed Matter Physics
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/TMTT.2004.831924

Cite this

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title = "Computational modeling evidence of a nonthermal electromagnetic interaction mechanism with living cells: Microwave nonlinearity in the cellular sodium ion channel",

abstract = "A computational hydrodynamics model consisting of a system of four coupled time-domain partial differential equations is applied to study the response of the cellular sodium ion channel to a microwave electric-field excitation. The model employs a dynamic conservation law formulation, which has not been previously applied to this problem. Results indicate that the cellular sodium ion channel exhibits an electrical nonlinearity at microwave frequencies, which generates an intermodulation spectrum when excited by an amplitude-modulated electric field. Intermodulation products having frequencies down to 50 MHz, and very likely well below 50 MHz, appear possible. This is a new nonthermal microwave interaction mechanism with living tissues that, if observable below 0.1 MHz, could enable the stimulation of excitable biological tissues, and thereby have significant implications for human health and safety.",

keywords = "Computational modeling, Electromagnetic interactions, Living cells, Microwaves, Nonlinearity, Nonthermal",

author = "Stoykov, {Nikolay S.} and Jerome, {Joseph W.} and Pierce, {Lauren C.} and Allen Taflove",

note = "Funding Information: Manuscript received July 8, 2003; revised February 13, 2004. This work was supported in part by the National Science Foundation under Grant DMS-0311263. N. S. Stoykov is with the Rehabilitation Institute of Chicago, Chicago, IL 60611 USA and also with the Department of Physical Medicine and Rehabilitation, Northwestern University, Chicago, IL 60611 USA (e-mail: [email protected]). J. W. Jerome is with the Department of Mathematics, Northwestern University, Evanston, IL 60208 USA. L. C. Pierce is with the Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL 60208 USA. A. Taflove is with the Department of Electrical and Computer Engineering, Northwestern University, Evanston, IL 60208 USA. Digital Object Identifier 10.1109/TMTT.2004.831924",

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Computational modeling evidence of a nonthermal electromagnetic interaction mechanism with living cells: Microwave nonlinearity in the cellular sodium ion channel. / Stoykov, Nikolay S.; Jerome, Joseph W.; Pierce, Lauren C. et al.
In: IEEE Transactions on Microwave Theory and Techniques, Vol. 52, No. 8 II, 08.2004, p. 2040-2045.

Research output: Contribution to journal › Article › peer-review

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AB - A computational hydrodynamics model consisting of a system of four coupled time-domain partial differential equations is applied to study the response of the cellular sodium ion channel to a microwave electric-field excitation. The model employs a dynamic conservation law formulation, which has not been previously applied to this problem. Results indicate that the cellular sodium ion channel exhibits an electrical nonlinearity at microwave frequencies, which generates an intermodulation spectrum when excited by an amplitude-modulated electric field. Intermodulation products having frequencies down to 50 MHz, and very likely well below 50 MHz, appear possible. This is a new nonthermal microwave interaction mechanism with living tissues that, if observable below 0.1 MHz, could enable the stimulation of excitable biological tissues, and thereby have significant implications for human health and safety.

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Computational modeling evidence of a nonthermal electromagnetic interaction mechanism with living cells: Microwave nonlinearity in the cellular sodium ion channel

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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