Computational modeling evidence of a nonthermal electromagnetic interaction mechanism with living cells: Microwave nonlinearity in the cellular sodium ion channel

Nikolay S. Stoykov*, Joseph W. Jerome, Lauren C. Pierce, Allen Taflove

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A computational hydrodynamics model consisting of a system of four coupled time-domain partial differential equations is applied to study the response of the cellular sodium ion channel to a microwave electric-field excitation. The model employs a dynamic conservation law formulation, which has not been previously applied to this problem. Results indicate that the cellular sodium ion channel exhibits an electrical nonlinearity at microwave frequencies, which generates an intermodulation spectrum when excited by an amplitude-modulated electric field. Intermodulation products having frequencies down to 50 MHz, and very likely well below 50 MHz, appear possible. This is a new nonthermal microwave interaction mechanism with living tissues that, if observable below 0.1 MHz, could enable the stimulation of excitable biological tissues, and thereby have significant implications for human health and safety.

Original languageEnglish (US)
Pages (from-to)2040-2045
Number of pages6
JournalIEEE Transactions on Microwave Theory and Techniques
Volume52
Issue number8 II
DOIs
StatePublished - Aug 2004

Keywords

  • Computational modeling
  • Electromagnetic interactions
  • Living cells
  • Microwaves
  • Nonlinearity
  • Nonthermal

ASJC Scopus subject areas

  • Radiation
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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