Computational models for the determination of depth-dependent mechanical properties of skin with a soft, flexible measurement device

Jianghong Yuan; Canan Dagdeviren; Yan Shi; Yinji Ma; Xue Feng; John A. Rogers; Yonggang Huang

doi:10.1098/rspa.2016.0225

Computational models for the determination of depth-dependent mechanical properties of skin with a soft, flexible measurement device

Jianghong Yuan, Canan Dagdeviren, Yan Shi, Yinji Ma, Xue Feng, John A. Rogers^*, Yonggang Huang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Conformal modulus sensors (CMS) incorporate PZT nanoribbons as mechanical actuators and sensors to achieve reversible conformal contact with the human skin for non-invasive, in vivo measurements of skin modulus. An analytic model presented in this paper yields expressions that connect the sensor output voltage to the Young moduli of the epidermis and dermis, the thickness of the epidermis, as well as the material and geometrical parameters of the CMS device itself and its encapsulation layer. Results from the model agree well with in vitro experiments on bilayer structures of poly(dimethylsiloxane). These results provide a means to determine the skin moduli (epidermis and dermis) and the thickness of the epidermis from in vivo measurements of human skin.

Original language	English (US)
Article number	20160225
Journal	Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences
Volume	472
Issue number	2194
DOIs	https://doi.org/10.1098/rspa.2016.0225
State	Published - Oct 1 2016

Funding

J.Y. acknowledges the support from the National Natural Science Foundation of China (grant no. 11402133). X.F. acknowledges the support from the National Basic Research Programme of China (grant no. 2015CB351900) and the National Natural Science Foundation of China (grant no. 11320101001). Y.H. acknowledges the support from the US National Science Foundation (grant nos. DMR-1121262, CMMI-1534120, CMMI-1300846 and CMMI-1400169) and from the US National Institutes of Health (grant no. R01EB019337).

Keywords

Conformal modulus sensors
Electromechanical coupling
Epidermis and dermis
Skin moduli

ASJC Scopus subject areas

General Mathematics
General Engineering
General Physics and Astronomy

Access to Document

10.1098/rspa.2016.0225

Cite this

Yuan, J., Dagdeviren, C., Shi, Y., Ma, Y., Feng, X., Rogers, J. A., & Huang, Y. (2016). Computational models for the determination of depth-dependent mechanical properties of skin with a soft, flexible measurement device. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 472(2194), Article 20160225. https://doi.org/10.1098/rspa.2016.0225

@article{d4c9ea1cd8b04d32a65e6ea1ae264451,

title = "Computational models for the determination of depth-dependent mechanical properties of skin with a soft, flexible measurement device",

abstract = "Conformal modulus sensors (CMS) incorporate PZT nanoribbons as mechanical actuators and sensors to achieve reversible conformal contact with the human skin for non-invasive, in vivo measurements of skin modulus. An analytic model presented in this paper yields expressions that connect the sensor output voltage to the Young moduli of the epidermis and dermis, the thickness of the epidermis, as well as the material and geometrical parameters of the CMS device itself and its encapsulation layer. Results from the model agree well with in vitro experiments on bilayer structures of poly(dimethylsiloxane). These results provide a means to determine the skin moduli (epidermis and dermis) and the thickness of the epidermis from in vivo measurements of human skin.",

keywords = "Conformal modulus sensors, Electromechanical coupling, Epidermis and dermis, Skin moduli",

author = "Jianghong Yuan and Canan Dagdeviren and Yan Shi and Yinji Ma and Xue Feng and Rogers, {John A.} and Yonggang Huang",

year = "2016",

month = oct,

day = "1",

doi = "10.1098/rspa.2016.0225",

language = "English (US)",

volume = "472",

journal = "Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences",

issn = "1364-5021",

publisher = "Royal Society of London",

number = "2194",

}

Computational models for the determination of depth-dependent mechanical properties of skin with a soft, flexible measurement device. / Yuan, Jianghong; Dagdeviren, Canan; Shi, Yan et al.
In: Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 472, No. 2194, 20160225, 01.10.2016.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Computational models for the determination of depth-dependent mechanical properties of skin with a soft, flexible measurement device

AU - Yuan, Jianghong

AU - Dagdeviren, Canan

AU - Shi, Yan

AU - Ma, Yinji

AU - Feng, Xue

AU - Rogers, John A.

AU - Huang, Yonggang

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Conformal modulus sensors (CMS) incorporate PZT nanoribbons as mechanical actuators and sensors to achieve reversible conformal contact with the human skin for non-invasive, in vivo measurements of skin modulus. An analytic model presented in this paper yields expressions that connect the sensor output voltage to the Young moduli of the epidermis and dermis, the thickness of the epidermis, as well as the material and geometrical parameters of the CMS device itself and its encapsulation layer. Results from the model agree well with in vitro experiments on bilayer structures of poly(dimethylsiloxane). These results provide a means to determine the skin moduli (epidermis and dermis) and the thickness of the epidermis from in vivo measurements of human skin.

AB - Conformal modulus sensors (CMS) incorporate PZT nanoribbons as mechanical actuators and sensors to achieve reversible conformal contact with the human skin for non-invasive, in vivo measurements of skin modulus. An analytic model presented in this paper yields expressions that connect the sensor output voltage to the Young moduli of the epidermis and dermis, the thickness of the epidermis, as well as the material and geometrical parameters of the CMS device itself and its encapsulation layer. Results from the model agree well with in vitro experiments on bilayer structures of poly(dimethylsiloxane). These results provide a means to determine the skin moduli (epidermis and dermis) and the thickness of the epidermis from in vivo measurements of human skin.

KW - Conformal modulus sensors

KW - Electromechanical coupling

KW - Epidermis and dermis

KW - Skin moduli

UR - http://www.scopus.com/inward/record.url?scp=84992053221&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992053221&partnerID=8YFLogxK

U2 - 10.1098/rspa.2016.0225

DO - 10.1098/rspa.2016.0225

M3 - Article

C2 - 27843395

AN - SCOPUS:84992053221

SN - 1364-5021

VL - 472

JO - Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences

JF - Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences

IS - 2194

M1 - 20160225

ER -

Computational models for the determination of depth-dependent mechanical properties of skin with a soft, flexible measurement device

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this