Computational models for the determination of depth-dependent mechanical properties of skin with a soft, flexible measurement device

Jianghong Yuan; Canan Dagdeviren; Yan Shi; Yinji Ma; Xue Feng; John A. Rogers; Yonggang Huang

doi:10.1098/rspa.2016.0225

Computational models for the determination of depth-dependent mechanical properties of skin with a soft, flexible measurement device

Jianghong Yuan, Canan Dagdeviren, Yan Shi, Yinji Ma, Xue Feng, John A. Rogers^*, Yonggang Huang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Conformal modulus sensors (CMS) incorporate PZT nanoribbons as mechanical actuators and sensors to achieve reversible conformal contact with the human skin for non-invasive, in vivo measurements of skin modulus. An analytic model presented in this paper yields expressions that connect the sensor output voltage to the Young moduli of the epidermis and dermis, the thickness of the epidermis, as well as the material and geometrical parameters of the CMS device itself and its encapsulation layer. Results from the model agree well with in vitro experiments on bilayer structures of poly(dimethylsiloxane). These results provide a means to determine the skin moduli (epidermis and dermis) and the thickness of the epidermis from in vivo measurements of human skin.

Original language	English (US)
Article number	20160225
Journal	Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences
Volume	472
Issue number	2194
DOIs	https://doi.org/10.1098/rspa.2016.0225
State	Published - Oct 1 2016

Keywords

Conformal modulus sensors
Electromechanical coupling
Epidermis and dermis
Skin moduli

ASJC Scopus subject areas

Mathematics(all)
Engineering(all)
Physics and Astronomy(all)

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10.1098/rspa.2016.0225

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title = "Computational models for the determination of depth-dependent mechanical properties of skin with a soft, flexible measurement device",

abstract = "Conformal modulus sensors (CMS) incorporate PZT nanoribbons as mechanical actuators and sensors to achieve reversible conformal contact with the human skin for non-invasive, in vivo measurements of skin modulus. An analytic model presented in this paper yields expressions that connect the sensor output voltage to the Young moduli of the epidermis and dermis, the thickness of the epidermis, as well as the material and geometrical parameters of the CMS device itself and its encapsulation layer. Results from the model agree well with in vitro experiments on bilayer structures of poly(dimethylsiloxane). These results provide a means to determine the skin moduli (epidermis and dermis) and the thickness of the epidermis from in vivo measurements of human skin.",

keywords = "Conformal modulus sensors, Electromechanical coupling, Epidermis and dermis, Skin moduli",

author = "Jianghong Yuan and Canan Dagdeviren and Yan Shi and Yinji Ma and Xue Feng and Rogers, {John A.} and Yonggang Huang",

note = "Funding Information: J.Y. acknowledges the support from the National Natural Science Foundation of China (grant no. 11402133). X.F. acknowledges the support from the National Basic Research Programme of China (grant no. 2015CB351900) and the National Natural Science Foundation of China (grant no. 11320101001). Y.H. acknowledges the support from the US National Science Foundation (grant nos. DMR-1121262, CMMI-1534120, CMMI-1300846 and CMMI-1400169) and from the US National Institutes of Health (grant no. R01EB019337). Publisher Copyright: {\textcopyright} 2016 The Author(s) Published by the Royal Society. All rights reserved.",

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Computational models for the determination of depth-dependent mechanical properties of skin with a soft, flexible measurement device. / Yuan, Jianghong; Dagdeviren, Canan; Shi, Yan et al.

In: Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 472, No. 2194, 20160225, 01.10.2016.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Computational models for the determination of depth-dependent mechanical properties of skin with a soft, flexible measurement device

AU - Yuan, Jianghong

AU - Dagdeviren, Canan

AU - Shi, Yan

AU - Ma, Yinji

AU - Feng, Xue

AU - Rogers, John A.

AU - Huang, Yonggang

N1 - Funding Information: J.Y. acknowledges the support from the National Natural Science Foundation of China (grant no. 11402133). X.F. acknowledges the support from the National Basic Research Programme of China (grant no. 2015CB351900) and the National Natural Science Foundation of China (grant no. 11320101001). Y.H. acknowledges the support from the US National Science Foundation (grant nos. DMR-1121262, CMMI-1534120, CMMI-1300846 and CMMI-1400169) and from the US National Institutes of Health (grant no. R01EB019337). Publisher Copyright: © 2016 The Author(s) Published by the Royal Society. All rights reserved.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Conformal modulus sensors (CMS) incorporate PZT nanoribbons as mechanical actuators and sensors to achieve reversible conformal contact with the human skin for non-invasive, in vivo measurements of skin modulus. An analytic model presented in this paper yields expressions that connect the sensor output voltage to the Young moduli of the epidermis and dermis, the thickness of the epidermis, as well as the material and geometrical parameters of the CMS device itself and its encapsulation layer. Results from the model agree well with in vitro experiments on bilayer structures of poly(dimethylsiloxane). These results provide a means to determine the skin moduli (epidermis and dermis) and the thickness of the epidermis from in vivo measurements of human skin.

AB - Conformal modulus sensors (CMS) incorporate PZT nanoribbons as mechanical actuators and sensors to achieve reversible conformal contact with the human skin for non-invasive, in vivo measurements of skin modulus. An analytic model presented in this paper yields expressions that connect the sensor output voltage to the Young moduli of the epidermis and dermis, the thickness of the epidermis, as well as the material and geometrical parameters of the CMS device itself and its encapsulation layer. Results from the model agree well with in vitro experiments on bilayer structures of poly(dimethylsiloxane). These results provide a means to determine the skin moduli (epidermis and dermis) and the thickness of the epidermis from in vivo measurements of human skin.

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Computational models for the determination of depth-dependent mechanical properties of skin with a soft, flexible measurement device

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