Abstract
Isolated tumor cells of the transplantable pancreatic acinar cell carcinoma of the rat [8] were found to have numerous microvilli by scanning electron microscopy (SEM) when compared to normal acinar cells of the rat pancreas, and were more susceptible to agglutination by concanavalin A (ConA) than the normal acinar cells. However, isolated normal pancreatic acinar cells developed increased numbers of microvilli and microplicae upon 10 min in vitro stimulation with secretin, but this was not associated with an enhancement of concanavalin A-mediated agglutinability. It appears, therefore, that there is a lack of correlation between surface microvilli and lectin agglutinability for acinar cells of the rat pancreas. The neoplastic acinar cells isolated from the transplantable pancreatic acinar carcinoma of the rat should prove to be of value in delinearing differences in cell surface biology of normal and neoplastic epithelial cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 55-61 |
| Number of pages | 7 |
| Journal | Experimental Cell Research |
| Volume | 120 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 1979 |
Funding
This investigation was supported by Grant CA23055 awarded by the NCI, US Department of Health, Education and Welfare. The authors gratefully acknowledge the technical assistance of Linnea Hansen.
ASJC Scopus subject areas
- Cell Biology
