Concanavalin-A-induced open neural tube defects in chick embryos

Takayuki Inagaki*, Kyu Chang Wang, Russell G. Higbee, David G. Mclone, Paul A. Knepper

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Open neural tube defects developed in 12 of 122 alive chick embryos treated with exogenous lectin (concanavalin-A) at stages between 10 or 14 as defined by Hamburger and Hamilton. Embryos treated at stage 10, the time of anterior neuropore closure, developed exencephaly or extensive neural openings from the level of rhombencephalon to the thoracic spinal cord, while embryos treated at stages between 11 and 14, at posterior neuropore closure, developed only small myeloschisis in the thoracolumbar region. The failure of neural tube closure at a critical time is a major cause of neural tube defects.

Original languageEnglish (US)
Pages (from-to)691-697
Number of pages7
JournalNeurologia medico-chirurgica
Issue number10
StatePublished - Oct 1996


  • chick embryo
  • closure defect
  • concanavalin-A
  • neural tube defect

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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