Concomitant Diabetes Mellitus and Heart Failure

Alessandra Dei Cas, Gregg C. Fonarow, Mihai Gheorghiade, Javed Butler

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


The prevalence of patients with concomitant diabetes mellitus (DM) and heart failure (HF) is growing exponentially. Patients with HF and DM show specific metabolic, neurohormonal, and structural heart abnormalities, which potentially contribute to worse HF outcomes than seen in patients without comorbid DM. Subgroup analysis of recent trials suggest that patients with HF and DM may respond differently to standard therapy, and data are emerging on the possible increase in the risk of hospitalizations for HF in patients with DM treated with specific class of antidiabetic agents, pointing to the need of developing specific medications to be tested in dedicated future studies to address the unique metabolic and hemodynamic alterations seen in these patients.

Original languageEnglish (US)
Pages (from-to)7-43
Number of pages37
JournalCurrent Problems in Cardiology
Issue number1
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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