Concurrence of Alzheimer's disease, Parkinson's disease, diffuse Lewy body disease, and amyotrophic lateral sclerosis

Peter Hedera, Alan J. Lerner, Rudy Castellani, Robert P. Friedland*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

A 71-year-old man developed signs of progressive dementia, followed by extrapyramidal and motor neuron disease symptoms, which led to death in 6 years. Neuropathological examination revealed neuritic plaques, neurofibrillary tangles, and Lewy bodies in the substantia nigra and neocortex. Atrophy and gliosis with intraneuronal ubiquitin inclusions were present in the anterior horns of the spinal cord. Overlapping of Alzheimer's disease, Parkinson's disease, diffuse Lewy body disease and amyotrophic lateral sclerosis is rare and can increase our understanding of the process of neurodegeneration.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalJournal of the Neurological Sciences
Volume128
Issue number2
DOIs
StatePublished - Feb 1995

Keywords

  • Alzheimer's disease
  • Amyotrophic lateral sclerosis
  • Dementia
  • Diffuse Lewy body disease
  • Parkinson's disease
  • Ubiquitin

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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