Abstract
A 71-year-old man developed signs of progressive dementia, followed by extrapyramidal and motor neuron disease symptoms, which led to death in 6 years. Neuropathological examination revealed neuritic plaques, neurofibrillary tangles, and Lewy bodies in the substantia nigra and neocortex. Atrophy and gliosis with intraneuronal ubiquitin inclusions were present in the anterior horns of the spinal cord. Overlapping of Alzheimer's disease, Parkinson's disease, diffuse Lewy body disease and amyotrophic lateral sclerosis is rare and can increase our understanding of the process of neurodegeneration.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 219-224 |
| Number of pages | 6 |
| Journal | Journal of the Neurological Sciences |
| Volume | 128 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1995 |
Funding
Supported in part by NIH grant AG 08012-05a nd Philip Morris, USA. The authors are indebted to Dr. Lars Gustafsono f the University of Lund for investigation of family history, and to Drs. M. Cohen and P-L. Gambetti for helpful discussion.T he contribution of Dr. N. Tresser to the pathological diagnosis is also acknowledged.
Keywords
- Alzheimer's disease
- Amyotrophic lateral sclerosis
- Dementia
- Diffuse Lewy body disease
- Parkinson's disease
- Ubiquitin
ASJC Scopus subject areas
- Clinical Neurology
- Neurology