Concurrence of Alzheimer's disease, Parkinson's disease, diffuse Lewy body disease, and amyotrophic lateral sclerosis

Peter Hedera; Alan J. Lerner; Rudy Castellani; Robert P. Friedland

doi:10.1016/0022-510X(94)00222-A

Concurrence of Alzheimer's disease, Parkinson's disease, diffuse Lewy body disease, and amyotrophic lateral sclerosis

Peter Hedera, Alan J. Lerner, Rudy Castellani, Robert P. Friedland^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A 71-year-old man developed signs of progressive dementia, followed by extrapyramidal and motor neuron disease symptoms, which led to death in 6 years. Neuropathological examination revealed neuritic plaques, neurofibrillary tangles, and Lewy bodies in the substantia nigra and neocortex. Atrophy and gliosis with intraneuronal ubiquitin inclusions were present in the anterior horns of the spinal cord. Overlapping of Alzheimer's disease, Parkinson's disease, diffuse Lewy body disease and amyotrophic lateral sclerosis is rare and can increase our understanding of the process of neurodegeneration.

Original language	English (US)
Pages (from-to)	219-224
Number of pages	6
Journal	Journal of the Neurological Sciences
Volume	128
Issue number	2
DOIs	https://doi.org/10.1016/0022-510X(94)00222-A
State	Published - Feb 1995

Keywords

Alzheimer's disease
Amyotrophic lateral sclerosis
Dementia
Diffuse Lewy body disease
Parkinson's disease
Ubiquitin

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/0022-510X(94)00222-A

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title = "Concurrence of Alzheimer's disease, Parkinson's disease, diffuse Lewy body disease, and amyotrophic lateral sclerosis",

abstract = "A 71-year-old man developed signs of progressive dementia, followed by extrapyramidal and motor neuron disease symptoms, which led to death in 6 years. Neuropathological examination revealed neuritic plaques, neurofibrillary tangles, and Lewy bodies in the substantia nigra and neocortex. Atrophy and gliosis with intraneuronal ubiquitin inclusions were present in the anterior horns of the spinal cord. Overlapping of Alzheimer's disease, Parkinson's disease, diffuse Lewy body disease and amyotrophic lateral sclerosis is rare and can increase our understanding of the process of neurodegeneration.",

keywords = "Alzheimer's disease, Amyotrophic lateral sclerosis, Dementia, Diffuse Lewy body disease, Parkinson's disease, Ubiquitin",

author = "Peter Hedera and Lerner, {Alan J.} and Rudy Castellani and Friedland, {Robert P.}",

note = "Funding Information: Supported in part by NIH grant AG 08012-05a nd Philip Morris, USA. The authors are indebted to Dr. Lars Gustafsono f the University of Lund for investigation of family history, and to Drs. M. Cohen and P-L. Gambetti for helpful discussion.T he contribution of Dr. N. Tresser to the pathological diagnosis is also acknowledged.",

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doi = "10.1016/0022-510X(94)00222-A",

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AU - Lerner, Alan J.

AU - Castellani, Rudy

AU - Friedland, Robert P.

N1 - Funding Information: Supported in part by NIH grant AG 08012-05a nd Philip Morris, USA. The authors are indebted to Dr. Lars Gustafsono f the University of Lund for investigation of family history, and to Drs. M. Cohen and P-L. Gambetti for helpful discussion.T he contribution of Dr. N. Tresser to the pathological diagnosis is also acknowledged.

PY - 1995/2

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N2 - A 71-year-old man developed signs of progressive dementia, followed by extrapyramidal and motor neuron disease symptoms, which led to death in 6 years. Neuropathological examination revealed neuritic plaques, neurofibrillary tangles, and Lewy bodies in the substantia nigra and neocortex. Atrophy and gliosis with intraneuronal ubiquitin inclusions were present in the anterior horns of the spinal cord. Overlapping of Alzheimer's disease, Parkinson's disease, diffuse Lewy body disease and amyotrophic lateral sclerosis is rare and can increase our understanding of the process of neurodegeneration.

AB - A 71-year-old man developed signs of progressive dementia, followed by extrapyramidal and motor neuron disease symptoms, which led to death in 6 years. Neuropathological examination revealed neuritic plaques, neurofibrillary tangles, and Lewy bodies in the substantia nigra and neocortex. Atrophy and gliosis with intraneuronal ubiquitin inclusions were present in the anterior horns of the spinal cord. Overlapping of Alzheimer's disease, Parkinson's disease, diffuse Lewy body disease and amyotrophic lateral sclerosis is rare and can increase our understanding of the process of neurodegeneration.

KW - Alzheimer's disease

KW - Amyotrophic lateral sclerosis

KW - Dementia

KW - Diffuse Lewy body disease

KW - Parkinson's disease

KW - Ubiquitin

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Concurrence of Alzheimer's disease, Parkinson's disease, diffuse Lewy body disease, and amyotrophic lateral sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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