TY - JOUR
T1 - Concurrence of Alzheimer's disease, Parkinson's disease, diffuse Lewy body disease, and amyotrophic lateral sclerosis
AU - Hedera, Peter
AU - Lerner, Alan J.
AU - Castellani, Rudy
AU - Friedland, Robert P.
N1 - Funding Information:
Supported in part by NIH grant AG 08012-05a nd Philip Morris, USA. The authors are indebted to Dr. Lars Gustafsono f the University of Lund for investigation of family history, and to Drs. M. Cohen and P-L. Gambetti for helpful discussion.T he contribution of Dr. N. Tresser to the pathological diagnosis is also acknowledged.
PY - 1995/2
Y1 - 1995/2
N2 - A 71-year-old man developed signs of progressive dementia, followed by extrapyramidal and motor neuron disease symptoms, which led to death in 6 years. Neuropathological examination revealed neuritic plaques, neurofibrillary tangles, and Lewy bodies in the substantia nigra and neocortex. Atrophy and gliosis with intraneuronal ubiquitin inclusions were present in the anterior horns of the spinal cord. Overlapping of Alzheimer's disease, Parkinson's disease, diffuse Lewy body disease and amyotrophic lateral sclerosis is rare and can increase our understanding of the process of neurodegeneration.
AB - A 71-year-old man developed signs of progressive dementia, followed by extrapyramidal and motor neuron disease symptoms, which led to death in 6 years. Neuropathological examination revealed neuritic plaques, neurofibrillary tangles, and Lewy bodies in the substantia nigra and neocortex. Atrophy and gliosis with intraneuronal ubiquitin inclusions were present in the anterior horns of the spinal cord. Overlapping of Alzheimer's disease, Parkinson's disease, diffuse Lewy body disease and amyotrophic lateral sclerosis is rare and can increase our understanding of the process of neurodegeneration.
KW - Alzheimer's disease
KW - Amyotrophic lateral sclerosis
KW - Dementia
KW - Diffuse Lewy body disease
KW - Parkinson's disease
KW - Ubiquitin
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U2 - 10.1016/0022-510X(94)00222-A
DO - 10.1016/0022-510X(94)00222-A
M3 - Article
C2 - 7738598
AN - SCOPUS:0028831034
SN - 0022-510X
VL - 128
SP - 219
EP - 224
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 2
ER -