Conditional dendritic spike propagation following distal synaptic activation of hippocampal CA1 pyramidal neurons

Tim Jarsky, Alex Roxin, William L Kath, Nelson Spruston*

*Corresponding author for this work

Research output: Contribution to journalArticle

182 Scopus citations

Abstract

The perforant-path projection to the hippocampus forms synapses in the apical tuft of CA1 pyramidal neurons. We used computer modeling to examine the function of these distal synaptic inputs, which led to three predictions that we confirmed in experiments using rat hippocampal slices. First, activation of CA1 neurons by the perforant path is limited, a result of the long distance between these inputs and the soma. Second, activation of CA1 neurons by the perforant path depends on the generation of dendritic spikes. Third, the forward propagation of these spikes is unreliable, but can be facilitated by modest activation of Schaffer-collateral synapses in the upper apical dendrites. This 'gating' of dendritic spike propagation may be an important activation mode of CA1 pyramidal neurons, and its modulation by neurotransmitters or long-term, activity-dependent plasticity may be an important feature of dendritic integration during mnemonic processing in the hippocampus.

Original languageEnglish (US)
Pages (from-to)1667-1676
Number of pages10
JournalNature Neuroscience
Volume8
Issue number12
DOIs
StatePublished - Dec 1 2005

ASJC Scopus subject areas

  • Neuroscience(all)

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