Conditional Discrimination Learning in Patients with Bilateral Medial Temporal Lobe Amnesia

Catherine Brawn Fortier*, John F. Disterhoft, Stephen Capozzi, Patrick Kilduff, Alice Cronin-Golomb, Regina E. McGlinchey

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The ability of bilateral medial temporal lobe amnesic patients (MT; n = 8) and normal participants (NC; n = 8) to acquire a conditional discrimination in trace and delay eyeblink conditioning paradigms was investigated. Experiment 1 assessed trace conditional discrimination learning by using a light conditional stimulus (S+/S-) and tone conditioned stimulus (CS) separated by a 1-s trace. NCs responded differentially on S+ trials (mean percent conditioned responses = 66) versus S - trials (30), whereas MTs were impaired in their acquisition of the conditional discrimination (S+ = 51, S- = 43). In Experiment 2, the temporal separation was eliminated. NCs acquired the conditional discrimination (S+ = 70, S- = 29). MTs were unable to respond differentially (S+ = 42, S- = 37). The findings indicate that the hippocampal system is essential in acquiring a conditional discrimination, even in a delay paradigm.

Original languageEnglish (US)
Pages (from-to)1181-1195
Number of pages15
JournalBehavioral Neuroscience
Volume117
Issue number6
DOIs
StatePublished - Dec 2003

ASJC Scopus subject areas

  • Behavioral Neuroscience

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