Conductance changes associated with the secretory potential in the cockroach salivary gland

B. L. Ginsborg*, C. R. House, E. M. Silinsky

*Corresponding author for this work

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

1. Conductance changes in the acini of the cockroach salivary gland have been examined during nerve stimulation by means of two intracellular electrodes placed in the same acinus, the first electrode being used for recording membrane potential and the second for current injection. 2. The transient hyperpolarization (secretory potential) in the acinus evoked by nerve stimuli is accompanied by a rise in membrane conductance. The conductance, however, remains high for a longer period than that of the response. 3. Applying the analysis of Trautwein & Dudel (1958) to the secretory potentials recorded in the acinus (assumed to behave electrically like a single cell) gives estimates of the ‘transmitter equilibrium potential’. The values indicate that the neurotransmitter increases the membrane potassium conductance. 4. The hyperpolarization of the acinus evoked by 10−6 M dopamine in the bathing fluid is also associated with an increase in membrane potassium conductance.

Original languageEnglish (US)
Pages (from-to)723-731
Number of pages9
JournalThe Journal of Physiology
Volume236
Issue number3
DOIs
StatePublished - Feb 1 1974

ASJC Scopus subject areas

  • Physiology

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