Conformational control of thymine photodimerization in single-strand and duplex DNA containing locked nucleic acid TT steps

Mahesh Hariharan; Martin McCullagh; George C Schatz; Frederick D Lewis

doi:10.1021/ja106203q

Conformational control of thymine photodimerization in single-strand and duplex DNA containing locked nucleic acid TT steps

Mahesh Hariharan, Martin McCullagh, George C Schatz, Frederick D Lewis

Chemistry

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The results of an integrated experimental and theoretical study of thymine-thymine photodimerization in short single-strand and duplex DNA structures possessing a single locked nucleic acid TT step are reported. Control of ground-state conformation by the locked nucleic acids results in a marked increase in both the quantum yield and the selectivity of photoproduct formation.

Original language	English (US)
Pages (from-to)	12856-12858
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	132
Issue number	37
DOIs	https://doi.org/10.1021/ja106203q
State	Published - Sep 22 2010

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja106203q

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title = "Conformational control of thymine photodimerization in single-strand and duplex DNA containing locked nucleic acid TT steps",

abstract = "The results of an integrated experimental and theoretical study of thymine-thymine photodimerization in short single-strand and duplex DNA structures possessing a single locked nucleic acid TT step are reported. Control of ground-state conformation by the locked nucleic acids results in a marked increase in both the quantum yield and the selectivity of photoproduct formation.",

author = "Mahesh Hariharan and Martin McCullagh and Schatz, {George C} and Lewis, {Frederick D}",

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AU - Schatz, George C

AU - Lewis, Frederick D

PY - 2010/9/22

Y1 - 2010/9/22

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AB - The results of an integrated experimental and theoretical study of thymine-thymine photodimerization in short single-strand and duplex DNA structures possessing a single locked nucleic acid TT step are reported. Control of ground-state conformation by the locked nucleic acids results in a marked increase in both the quantum yield and the selectivity of photoproduct formation.

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Conformational control of thymine photodimerization in single-strand and duplex DNA containing locked nucleic acid TT steps

Abstract

ASJC Scopus subject areas

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