Conformational dynamics of tryptophan: a proposal for the origin of the non-exponential fluorescence decay

Richard A. Engh; Lin X Q Chen; Graham R. Fleming

doi:10.1016/S0009-2614(86)80100-2

Conformational dynamics of tryptophan: a proposal for the origin of the non-exponential fluorescence decay

Richard A. Engh^*, Lin X Q Chen, Graham R. Fleming

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

A molecular dynamics simulation is used to explore the conformational dynamics of tryptophan. The simulations imply a substantial time scale separation for motion around the χ₁ or χ₂ bonds. We propose a model for tryptophan non-exponential fluorescence decay in terms of two χ₂ conformers each consisting of equilibrium distributions (on the fluorescence time scale) of χ₁ conformers.

Original language	English (US)
Pages (from-to)	365-372
Number of pages	8
Journal	Chemical Physics Letters
Volume	126
Issue number	3-4
DOIs	https://doi.org/10.1016/S0009-2614(86)80100-2
State	Published - May 9 1986

ASJC Scopus subject areas

Physics and Astronomy(all)
Physical and Theoretical Chemistry

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10.1016/S0009-2614(86)80100-2

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title = "Conformational dynamics of tryptophan: a proposal for the origin of the non-exponential fluorescence decay",

abstract = "A molecular dynamics simulation is used to explore the conformational dynamics of tryptophan. The simulations imply a substantial time scale separation for motion around the χ1 or χ2 bonds. We propose a model for tryptophan non-exponential fluorescence decay in terms of two χ2 conformers each consisting of equilibrium distributions (on the fluorescence time scale) of χ1 conformers.",

author = "Engh, {Richard A.} and Chen, {Lin X Q} and Fleming, {Graham R.}",

note = "Funding Information: This work was supported by an NSF grant. RAE is an NSF and McCormick Fellow. We thank Dr. Jacob Petrich for numerous helpful discussions and Dr. W. van Gunsteren for providing us with the GROMOS package.",

year = "1986",

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doi = "10.1016/S0009-2614(86)80100-2",

language = "English (US)",

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T1 - Conformational dynamics of tryptophan

T2 - a proposal for the origin of the non-exponential fluorescence decay

AU - Engh, Richard A.

AU - Chen, Lin X Q

AU - Fleming, Graham R.

N1 - Funding Information: This work was supported by an NSF grant. RAE is an NSF and McCormick Fellow. We thank Dr. Jacob Petrich for numerous helpful discussions and Dr. W. van Gunsteren for providing us with the GROMOS package.

PY - 1986/5/9

Y1 - 1986/5/9

N2 - A molecular dynamics simulation is used to explore the conformational dynamics of tryptophan. The simulations imply a substantial time scale separation for motion around the χ1 or χ2 bonds. We propose a model for tryptophan non-exponential fluorescence decay in terms of two χ2 conformers each consisting of equilibrium distributions (on the fluorescence time scale) of χ1 conformers.

AB - A molecular dynamics simulation is used to explore the conformational dynamics of tryptophan. The simulations imply a substantial time scale separation for motion around the χ1 or χ2 bonds. We propose a model for tryptophan non-exponential fluorescence decay in terms of two χ2 conformers each consisting of equilibrium distributions (on the fluorescence time scale) of χ1 conformers.

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U2 - 10.1016/S0009-2614(86)80100-2

DO - 10.1016/S0009-2614(86)80100-2

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VL - 126

SP - 365

EP - 372

JO - Chemical Physics Letters

JF - Chemical Physics Letters

IS - 3-4

ER -

Conformational dynamics of tryptophan: a proposal for the origin of the non-exponential fluorescence decay

Abstract

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