Conformational stability of the bacterial adhesin, FimH, with an inactivating mutation

Keyphrases

• Inactivating mutation 100%
• Bacterial Adhesins 100%
• FimH 100%
• Conformational Stability 100%
• Lectin Domain 80%
• Conformational Change 60%
• High Affinity 40%
• Allostery 40%
• Catch Bond 40%
• Two-component Domains 40%
• Minimal Model 40%
• Molecular Dynamics Simulation 20%
• Structural Information 20%
• Ligand Binding 20%
• Drug Development 20%
• Pilin 20%
• Adhesive Protein 20%
• Protein Dynamics 20%
• Adhesion 20%
• Thermodynamic Data 20%
• Preventing Infection 20%
• Pathogenic Bacteria 20%
• Tensile Force 20%
• Low Affinity 20%
• Active State 20%
• Inactive State 20%
• Coordinate System 20%
• Dihedral Angle 20%
• Binding Pocket 20%
• Conformational States 20%
• Allosteric Mechanism 20%
• Internal Coordinates 20%
• Allosteric Inhibition 20%
• Bond Behavior 20%
• Side-chain Dynamics 20%
• Bacteria Separation 20%

Biochemistry, Genetics and Molecular Biology

• Lectin 100%
• Bacterial Adhesin 100%
• Conformational Change 75%
• Allosteric Regulation 50%
• Dynamics 50%
• Conformation 25%
• Ligand Binding 25%
• Pilin 25%
• Arginine 25%
• Protein Dynamics 25%
• Dihedral Angle 25%