Congenital central hypoventilation syndrome (CCHS): Circadian temperature variation

Rehan Saiyed, Casey M. Rand, Michael Sean Carroll, Cynthia M. Koliboski, Tracey M. Stewart, Cindy D. Brogadir, Anna S. Kenny, Emily K.E. Petersen, David W. Carley, Debra E Weese-Mayer*

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Background Congenital central hypoventilation syndrome (CCHS) is a rare neurocristopathy, which includes a control of breathing deficit and features of autonomic nervous system (ANS) dysregulation. In recognition of the fundamental role of the ANS in temperature regulation and rhythm and the lack of any prior characterization of circadian temperature rhythms in CCHS, we sought to explore peripheral and core temperatures and circadian patterning. We hypothesized that CCHS patients would exhibit lower peripheral skin temperatures (PST), variability, and circadian rhythmicity (vs. controls), as well as a disrupted relationship between core body temperature (CBT) and PST. Methods PST was sampled every 3 min over four 24-hr periods in CCHS cases and similarly aged controls. CBT was sampled in a subset of these recordings. Results PST was recorded from 25 CCHS cases (110,664 measures/230 days) and 39 controls (78,772 measures/164 days). Simultaneous CBT measurements were made from 23 CCHS patients. In CCHS, mean PST was lower overall (P = 0.03) and at night (P = 0.02), and PST variability (interquartile range) was higher at night (P = 0.05) (vs. controls). PST circadian rhythm remained intact but the phase relationship of PST to CBT rhythm was extremely variable in CCHS. Conclusions PST alterations in CCHS likely reflect altered autonomic control of peripheral vascular tone. These alterations represent a previously unreported manifestation of CCHS and may provide an opportunity for therapeutic intervention. The relationship between temperature dysregulation and CCHS may also offer insight into basic mechanisms underlying thermoregulation. Pediatr Pulmonol. 2016;51:300-307.

Original languageEnglish (US)
Pages (from-to)300-307
Number of pages8
JournalPediatric Pulmonology
Volume51
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

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Keywords

  • PHOX2B gene
  • circadian rhythm
  • iButton
  • peripheral skin temperature

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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