Congenital dyserythropoietic anemia type II (CDA II) diagnosed in an adult patient

Bevan Tandon, Lo Ann C. Peterson, Stephanie Norwood, Anaadriana Zakarija, Yi Hua Chen*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The congenital dyserythropoietic anemias (CDAs) are a group of rare hereditary disorders characterized by ineffective erythropoiesis and distinct morphologic abnormalities of the erythroblasts in the bone marrow. CDA type II (CDA II) is the most common subtype, with more than 300 cases reported in the literature. Patients often present with anemia, jaundice, and variable splenomegaly. Most cases of CDA II are diagnosed at a young age; some patients, however, may remain unrecognized until late adulthood. Unless CDA is considered in the differential diagnosis for anemia, adult patients are often subjected to extensive clinical work-up for many years prior to accurate diagnosis. Early recognition of CDA II is important to prevent end-organ damage secondary to iron overload, the most important complication of the disease. We report a case of CDA II diagnosed in a 48-year-old woman with a longstanding history of anemia of unknown etiology.

Original languageEnglish (US)
Pages (from-to)149-153
Number of pages5
JournalJournal of Hematopathology
Volume3
Issue number4
DOIs
StatePublished - Dec 1 2010

Keywords

  • Anemia
  • Congenital dyserythropoietic anemia type II (CDA II)
  • Dyserythropoiesis
  • Hereditary erythroblastic multinuclearity with a positive acidified serum test (HEMPAS)
  • Ineffective erythropoiesis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Hematology

Fingerprint Dive into the research topics of 'Congenital dyserythropoietic anemia type II (CDA II) diagnosed in an adult patient'. Together they form a unique fingerprint.

  • Cite this