TY - JOUR
T1 - Congenital erosive and vesicular dermatosis with reticulated supple scarring
T2 - Unifying clinical features
AU - Tlougan, Brook E.
AU - Paller, Amy S.
AU - Schaffer, Julie V.
AU - Podjasek, Joshua O.
AU - Mandell, Jenny A.
AU - Nguyen, Xuan H.
AU - Spraker, Mary K.
AU - Hansen, Ronald C.
PY - 2013/12
Y1 - 2013/12
N2 - Background Congenital erosive and vesicular dermatosis (CEVD) healing with reticulated supple scarring, a condition usually observed in premature neonates, presents at birth with vesicles and erosions. Lesions typically heal within a few months, leaving behind scarring with a distinctive supple and reticulated texture. Objectives We sought to merge existing literature with new cases to further define CEVD. Methods We analyzed 19 previous reports of CEVD and added 9 additional patients; we identified unifying characteristics of this cohort. Results In 28 total cases, notable features included: preterm birth (79%), nail abnormalities (46%), hyperthermia/hypohidrosis (46%), a history of maternal chorioamnionitis (43%), alopecia (43%), neurodevelopmental and ophthalmologic abnormalities (36% each), tongue atrophy (29%), or a combination of these. Patients with CEVD may be prone to postnatal herpetic superinfections. Previously unreported findings included: erosive lichen planus, digital tip gangrene, and hydronephrosis. Limitations The small patient sampling makes it difficult to define diagnostic criteria. As certain findings are associated with prematurity, it is unclear to what extent these features result from CEVD, premature birth, or another intrauterine pathology. Conclusions Although rare, CEVD should be considered in the differential diagnosis of neonatal vesicles/erosions in the context of a negative infectious workup. This review strengthens the spectrum of CEVD features, thus facilitating its recognition by clinicians.
AB - Background Congenital erosive and vesicular dermatosis (CEVD) healing with reticulated supple scarring, a condition usually observed in premature neonates, presents at birth with vesicles and erosions. Lesions typically heal within a few months, leaving behind scarring with a distinctive supple and reticulated texture. Objectives We sought to merge existing literature with new cases to further define CEVD. Methods We analyzed 19 previous reports of CEVD and added 9 additional patients; we identified unifying characteristics of this cohort. Results In 28 total cases, notable features included: preterm birth (79%), nail abnormalities (46%), hyperthermia/hypohidrosis (46%), a history of maternal chorioamnionitis (43%), alopecia (43%), neurodevelopmental and ophthalmologic abnormalities (36% each), tongue atrophy (29%), or a combination of these. Patients with CEVD may be prone to postnatal herpetic superinfections. Previously unreported findings included: erosive lichen planus, digital tip gangrene, and hydronephrosis. Limitations The small patient sampling makes it difficult to define diagnostic criteria. As certain findings are associated with prematurity, it is unclear to what extent these features result from CEVD, premature birth, or another intrauterine pathology. Conclusions Although rare, CEVD should be considered in the differential diagnosis of neonatal vesicles/erosions in the context of a negative infectious workup. This review strengthens the spectrum of CEVD features, thus facilitating its recognition by clinicians.
KW - congenital erosive and vesicular dermatosis
KW - neonatal blistering
KW - neonatal vesicles
KW - neonate
KW - reticulated
KW - scarring
KW - supple
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U2 - 10.1016/j.jaad.2013.08.015
DO - 10.1016/j.jaad.2013.08.015
M3 - Article
C2 - 24099729
AN - SCOPUS:84888013893
SN - 0190-9622
VL - 69
SP - 909
EP - 915
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 6
ER -