Congenital Long-QT Syndromes: A Clinical and Genetic Update From Infancy Through Adulthood

Gregory Webster, Charles I. Berul*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Long-QT syndromes (LQTSs) have been described in all ages and are a significant cause of cardiovascular mortality, especially in structurally normal hearts. Abnormalities in transmembrane ion conduction channels and structural proteins produce these clinical syndromes, labeled LQT1-LQT12; however, genotype-positive patients still represent only about 70% of LQTSs. Future research will determine the etiology of the remaining cases, further risk-stratify the known genetic defects, improve current treatment options for these syndromes, and uncover novel therapies.

Original languageEnglish (US)
Pages (from-to)216-224
Number of pages9
JournalTrends in Cardiovascular Medicine
Volume18
Issue number6
DOIs
StatePublished - Aug 2008

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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