Congenital neurocristic tumor presenting as an isolated calvarial defect in an infant: Case report

Caroline Hadley, Carrie A. Mohila, Thomas G. Luerssen, Sandi Lam*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


In infants, the presence of a cranial defect may be due to a variety of traumatic, infammatory, neoplastic, and congenital abnormalities. Differentiation between these possible etiologies is facilitated by clinical presentation, patient history, and physical examination. Congenital cutaneous neural crest-derived lesions are unlikely to be considered in a patient presenting with an asymptomatic cranial defect without overlying mass or skin pigmentation. The authors present an unusual case of a 2-month-old infant with an asymptomatic calvarial defect with normal overlying skin. Pathology of the excised tissue showed features consistent with a congenital neurocristic tumor: a pigmented, neural crest-derived hamartomatous tumor that typically presents as a melanotic skin lesion.

Original languageEnglish (US)
Pages (from-to)46-49
Number of pages4
JournalJournal of Neurosurgery: Pediatrics
Issue number1
StatePublished - Jul 2015
Externally publishedYes


  • Calvarial lesion
  • Infant
  • Lytic bone lesion
  • Neurocristic
  • Oncology
  • Pediatric
  • Skull defect

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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