Congenital toxoplasmosis transmitted from an immunologically competent mother infected before conception

Nicolas Vogel; Michael Kirisits; Eric Michael; Howard Bach; Margaret Hostetter; Kenneth Boyer; Ross Simpson; Ellen Holfels; Joyce Hopkins; Douglas Mack; Marilyn B. Mets; Charles N. Swisher; Dushyant Patel; Nancy Roizen; Laszlo Stein; Mark Stein; Shawn Withers; Ernest Mui; Charles Egwuagu; Jack Remington; Ronald Dorfman; Rima McLeod

doi:10.1093/clinids/23.5.1055

Congenital toxoplasmosis transmitted from an immunologically competent mother infected before conception

Nicolas Vogel, Michael Kirisits, Eric Michael, Howard Bach, Margaret Hostetter, Kenneth Boyer, Ross Simpson, Ellen Holfels, Joyce Hopkins, Douglas Mack, Marilyn B. Mets, Charles N. Swisher, Dushyant Patel, Nancy Roizen, Laszlo Stein, Mark Stein, Shawn Withers, Ernest Mui, Charles Egwuagu, Jack RemingtonRonald Dorfman, Rima McLeod^*

^*Corresponding author for this work

Ophthalmology

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

Congenital transmission of Toxoplasma gondii from a mother who was apparently immunologically competent and who had toxoplasmic lymphadenitis 2 months before conception is described. Since no T. gondii-specific serological data were available for this mother from the time her lymph node biopsy specimen was obtained, the specimen was studied by polymerase chain reaction (PCR) to determine whether the T. gondii B1 gene was present. The predictive diagnostic value of histologic findings previously considered to be classic signs of T. gondii lymphadenitis also was studied. This was done by correlation of serological tests diagnostic of acute acquired T. gondii infection and presence of characteristic findings in biopsy specimens from persons without known immunocompromise. Both PCR and review of the characteristic features of her lymph node biopsy specimen confirmed the diagnosis of preconceptual infection in the mother. We also discuss two other cases in which apparently immunologically competent mothers with preconceptually acquired infection transmitted this parasite to their fetuses.

Original language	English (US)
Pages (from-to)	1055-1060
Number of pages	6
Journal	Clinical Infectious Diseases
Volume	23
Issue number	5
DOIs	https://doi.org/10.1093/clinids/23.5.1055
State	Published - 1996

Funding

Financial support: This work was supported by grants NIH NIAID AI 27530 and NIH AI 108749, the Research to Prevent Blindness (RPB) Foundation (Rima McLeod is the Jules and Doris Stein RPB Professor at the University of Chicago), and the Pillsbury Postdoctoral Scholar Award to Nicolas Vogel.

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

Access to Document

10.1093/clinids/23.5.1055

Cite this

Vogel, N., Kirisits, M., Michael, E., Bach, H., Hostetter, M., Boyer, K., Simpson, R., Holfels, E., Hopkins, J., Mack, D., Mets, M. B., Swisher, C. N., Patel, D., Roizen, N., Stein, L., Stein, M., Withers, S., Mui, E., Egwuagu, C., ... McLeod, R. (1996). Congenital toxoplasmosis transmitted from an immunologically competent mother infected before conception. Clinical Infectious Diseases, 23(5), 1055-1060. https://doi.org/10.1093/clinids/23.5.1055

@article{038a357767134433a759ae3f3bcb9afb,

title = "Congenital toxoplasmosis transmitted from an immunologically competent mother infected before conception",

abstract = "Congenital transmission of Toxoplasma gondii from a mother who was apparently immunologically competent and who had toxoplasmic lymphadenitis 2 months before conception is described. Since no T. gondii-specific serological data were available for this mother from the time her lymph node biopsy specimen was obtained, the specimen was studied by polymerase chain reaction (PCR) to determine whether the T. gondii B1 gene was present. The predictive diagnostic value of histologic findings previously considered to be classic signs of T. gondii lymphadenitis also was studied. This was done by correlation of serological tests diagnostic of acute acquired T. gondii infection and presence of characteristic findings in biopsy specimens from persons without known immunocompromise. Both PCR and review of the characteristic features of her lymph node biopsy specimen confirmed the diagnosis of preconceptual infection in the mother. We also discuss two other cases in which apparently immunologically competent mothers with preconceptually acquired infection transmitted this parasite to their fetuses.",

author = "Nicolas Vogel and Michael Kirisits and Eric Michael and Howard Bach and Margaret Hostetter and Kenneth Boyer and Ross Simpson and Ellen Holfels and Joyce Hopkins and Douglas Mack and Mets, {Marilyn B.} and Swisher, {Charles N.} and Dushyant Patel and Nancy Roizen and Laszlo Stein and Mark Stein and Shawn Withers and Ernest Mui and Charles Egwuagu and Jack Remington and Ronald Dorfman and Rima McLeod",

note = "Funding Information: Financial support: This work was supported by grants NIH NIAID AI 27530 and NIH AI 108749, the Research to Prevent Blindness (RPB) Foundation (Rima McLeod is the Jules and Doris Stein RPB Professor at the University of Chicago), and the Pillsbury Postdoctoral Scholar Award to Nicolas Vogel.",

year = "1996",

doi = "10.1093/clinids/23.5.1055",

language = "English (US)",

volume = "23",

pages = "1055--1060",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "5",

}

Vogel, N, Kirisits, M, Michael, E, Bach, H, Hostetter, M, Boyer, K, Simpson, R, Holfels, E, Hopkins, J, Mack, D, Mets, MB, Swisher, CN, Patel, D, Roizen, N, Stein, L, Stein, M, Withers, S, Mui, E, Egwuagu, C, Remington, J, Dorfman, R & McLeod, R 1996, 'Congenital toxoplasmosis transmitted from an immunologically competent mother infected before conception', Clinical Infectious Diseases, vol. 23, no. 5, pp. 1055-1060. https://doi.org/10.1093/clinids/23.5.1055

TY - JOUR

T1 - Congenital toxoplasmosis transmitted from an immunologically competent mother infected before conception

AU - Vogel, Nicolas

AU - Kirisits, Michael

AU - Michael, Eric

AU - Bach, Howard

AU - Hostetter, Margaret

AU - Boyer, Kenneth

AU - Simpson, Ross

AU - Holfels, Ellen

AU - Hopkins, Joyce

AU - Mack, Douglas

AU - Mets, Marilyn B.

AU - Swisher, Charles N.

AU - Patel, Dushyant

AU - Roizen, Nancy

AU - Stein, Laszlo

AU - Stein, Mark

AU - Withers, Shawn

AU - Mui, Ernest

AU - Egwuagu, Charles

AU - Remington, Jack

AU - Dorfman, Ronald

AU - McLeod, Rima

N1 - Funding Information: Financial support: This work was supported by grants NIH NIAID AI 27530 and NIH AI 108749, the Research to Prevent Blindness (RPB) Foundation (Rima McLeod is the Jules and Doris Stein RPB Professor at the University of Chicago), and the Pillsbury Postdoctoral Scholar Award to Nicolas Vogel.

PY - 1996

Y1 - 1996

N2 - Congenital transmission of Toxoplasma gondii from a mother who was apparently immunologically competent and who had toxoplasmic lymphadenitis 2 months before conception is described. Since no T. gondii-specific serological data were available for this mother from the time her lymph node biopsy specimen was obtained, the specimen was studied by polymerase chain reaction (PCR) to determine whether the T. gondii B1 gene was present. The predictive diagnostic value of histologic findings previously considered to be classic signs of T. gondii lymphadenitis also was studied. This was done by correlation of serological tests diagnostic of acute acquired T. gondii infection and presence of characteristic findings in biopsy specimens from persons without known immunocompromise. Both PCR and review of the characteristic features of her lymph node biopsy specimen confirmed the diagnosis of preconceptual infection in the mother. We also discuss two other cases in which apparently immunologically competent mothers with preconceptually acquired infection transmitted this parasite to their fetuses.

AB - Congenital transmission of Toxoplasma gondii from a mother who was apparently immunologically competent and who had toxoplasmic lymphadenitis 2 months before conception is described. Since no T. gondii-specific serological data were available for this mother from the time her lymph node biopsy specimen was obtained, the specimen was studied by polymerase chain reaction (PCR) to determine whether the T. gondii B1 gene was present. The predictive diagnostic value of histologic findings previously considered to be classic signs of T. gondii lymphadenitis also was studied. This was done by correlation of serological tests diagnostic of acute acquired T. gondii infection and presence of characteristic findings in biopsy specimens from persons without known immunocompromise. Both PCR and review of the characteristic features of her lymph node biopsy specimen confirmed the diagnosis of preconceptual infection in the mother. We also discuss two other cases in which apparently immunologically competent mothers with preconceptually acquired infection transmitted this parasite to their fetuses.

UR - http://www.scopus.com/inward/record.url?scp=19244363157&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19244363157&partnerID=8YFLogxK

U2 - 10.1093/clinids/23.5.1055

DO - 10.1093/clinids/23.5.1055

M3 - Article

C2 - 8922802

AN - SCOPUS:19244363157

SN - 1058-4838

VL - 23

SP - 1055

EP - 1060

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 5

ER -

Congenital toxoplasmosis transmitted from an immunologically competent mother infected before conception

Abstract

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this