Connection domain mutations during antiretroviral treatment failure in Mali: frequencies and impact on reverse transcriptase inhibitor activity.

Almoustapha Issiaka Maiga; Sudhir Penugonda; Drissa Katile; Fodie Diallo; Djeneba Bocar Fofana; Baiba Berzins; Moussa Youssouffa Maiga; Aliou Sylla; Hamar Alassane Traore; Anne Genevieve Marcelin; Vincent Calvez; Anatole Tounkara; Nobel Bellosillo; Robert Murphy; Babafemi O Taiwo

Connection domain mutations during antiretroviral treatment failure in Mali: frequencies and impact on reverse transcriptase inhibitor activity.

Almoustapha Issiaka Maiga^*, Sudhir Penugonda, Drissa Katile, Fodie Diallo, Djeneba Bocar Fofana, Baiba Berzins, Moussa Youssouffa Maiga, Aliou Sylla, Hamar Alassane Traore, Anne Genevieve Marcelin, Vincent Calvez, Anatole Tounkara, Nobel Bellosillo, Robert Murphy, Babafemi O Taiwo

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Mutations in the connection domain (CD) of reverse transcriptase have been implicated in reverse transcriptase inhibitor (RTI) resistance, but this is controversial and little is known in non-B subtype HIV-1. We determined CD mutations prevalence in a population infected predominantly with CRF02_AG and investigated associations with phenotypic RTI resistance. Detected CD mutations were G335D (82.3%), A371V (69.8%), E399D (9.4%), N348I (5.2%), V365I (4.2), Y318F (2.1%), G333E (2.1%), and A360V (2.1%). Mutations were largely polymorphic and did not confer RTI resistance. The observed trend toward reduced likelihood of etravirine or nevirapine resistance in the presence of G335D should be investigated further.

Original language	English (US)
Pages (from-to)	293-296
Number of pages	4
Journal	Journal of acquired immune deficiency syndromes (1999)
Volume	61
Issue number	3
State	Published - Nov 1 2012

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Maiga, A. I., Penugonda, S., Katile, D., Diallo, F., Fofana, D. B., Berzins, B., Maiga, M. Y., Sylla, A., Traore, H. A., Marcelin, A. G., Calvez, V., Tounkara, A., Bellosillo, N., Murphy, R., & Taiwo, B. O. (2012). Connection domain mutations during antiretroviral treatment failure in Mali: frequencies and impact on reverse transcriptase inhibitor activity. Journal of acquired immune deficiency syndromes (1999), 61(3), 293-296.

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title = "Connection domain mutations during antiretroviral treatment failure in Mali: frequencies and impact on reverse transcriptase inhibitor activity.",

abstract = "Mutations in the connection domain (CD) of reverse transcriptase have been implicated in reverse transcriptase inhibitor (RTI) resistance, but this is controversial and little is known in non-B subtype HIV-1. We determined CD mutations prevalence in a population infected predominantly with CRF02_AG and investigated associations with phenotypic RTI resistance. Detected CD mutations were G335D (82.3%), A371V (69.8%), E399D (9.4%), N348I (5.2%), V365I (4.2), Y318F (2.1%), G333E (2.1%), and A360V (2.1%). Mutations were largely polymorphic and did not confer RTI resistance. The observed trend toward reduced likelihood of etravirine or nevirapine resistance in the presence of G335D should be investigated further.",

author = "Maiga, {Almoustapha Issiaka} and Sudhir Penugonda and Drissa Katile and Fodie Diallo and Fofana, {Djeneba Bocar} and Baiba Berzins and Maiga, {Moussa Youssouffa} and Aliou Sylla and Traore, {Hamar Alassane} and Marcelin, {Anne Genevieve} and Vincent Calvez and Anatole Tounkara and Nobel Bellosillo and Robert Murphy and Taiwo, {Babafemi O}",

year = "2012",

month = nov,

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language = "English (US)",

volume = "61",

pages = "293--296",

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Maiga, AI, Penugonda, S, Katile, D, Diallo, F, Fofana, DB, Berzins, B, Maiga, MY, Sylla, A, Traore, HA, Marcelin, AG, Calvez, V, Tounkara, A, Bellosillo, N, Murphy, R & Taiwo, BO 2012, 'Connection domain mutations during antiretroviral treatment failure in Mali: frequencies and impact on reverse transcriptase inhibitor activity.', Journal of acquired immune deficiency syndromes (1999), vol. 61, no. 3, pp. 293-296.

Connection domain mutations during antiretroviral treatment failure in Mali: frequencies and impact on reverse transcriptase inhibitor activity. / Maiga, Almoustapha Issiaka; Penugonda, Sudhir; Katile, Drissa et al.
In: Journal of acquired immune deficiency syndromes (1999), Vol. 61, No. 3, 01.11.2012, p. 293-296.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Connection domain mutations during antiretroviral treatment failure in Mali

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AU - Maiga, Almoustapha Issiaka

AU - Penugonda, Sudhir

AU - Katile, Drissa

AU - Diallo, Fodie

AU - Fofana, Djeneba Bocar

AU - Berzins, Baiba

AU - Maiga, Moussa Youssouffa

AU - Sylla, Aliou

AU - Traore, Hamar Alassane

AU - Marcelin, Anne Genevieve

AU - Calvez, Vincent

AU - Tounkara, Anatole

AU - Bellosillo, Nobel

AU - Murphy, Robert

AU - Taiwo, Babafemi O

PY - 2012/11/1

Y1 - 2012/11/1

N2 - Mutations in the connection domain (CD) of reverse transcriptase have been implicated in reverse transcriptase inhibitor (RTI) resistance, but this is controversial and little is known in non-B subtype HIV-1. We determined CD mutations prevalence in a population infected predominantly with CRF02_AG and investigated associations with phenotypic RTI resistance. Detected CD mutations were G335D (82.3%), A371V (69.8%), E399D (9.4%), N348I (5.2%), V365I (4.2), Y318F (2.1%), G333E (2.1%), and A360V (2.1%). Mutations were largely polymorphic and did not confer RTI resistance. The observed trend toward reduced likelihood of etravirine or nevirapine resistance in the presence of G335D should be investigated further.

AB - Mutations in the connection domain (CD) of reverse transcriptase have been implicated in reverse transcriptase inhibitor (RTI) resistance, but this is controversial and little is known in non-B subtype HIV-1. We determined CD mutations prevalence in a population infected predominantly with CRF02_AG and investigated associations with phenotypic RTI resistance. Detected CD mutations were G335D (82.3%), A371V (69.8%), E399D (9.4%), N348I (5.2%), V365I (4.2), Y318F (2.1%), G333E (2.1%), and A360V (2.1%). Mutations were largely polymorphic and did not confer RTI resistance. The observed trend toward reduced likelihood of etravirine or nevirapine resistance in the presence of G335D should be investigated further.

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Connection domain mutations during antiretroviral treatment failure in Mali: frequencies and impact on reverse transcriptase inhibitor activity.

Abstract

ASJC Scopus subject areas

UN SDGs

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