Connectivity changes after laser ablation: Resting-state fMRI

Varina L. Boerwinkle*, Aditya Vedantam, Sandi Lam, Angus A. Wilfong, Daniel J. Curry

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Resting-state functional magnetic resonance imaging (rsfMRI) is emerging as a useful tool in the multimodal assessment of patients with epilepsy. In pediatric patients who cannot perform task-based fMRI, rsfMRI may present an adjunct and alternative. Although changes in brain activation during task-based fMRI have been described after surgery for epilepsy, there is limited data on the role of postoperative rsfMRI. In this short review, we discuss the role of postoperative rsfMRI after laser ablation of seizure foci. By establishing standardized anesthesia protocols and imaging parameters, we have been able to perform serial rsfMRI at postoperative follow-up. The development of in-house software that can merge rsfMRI images to surgical navigation systems has allowed us to enhance the clinical applications of this technique. Resting-state fMRI after laser ablation has the potential to identify changes in connectivity, localize new seizure foci, and guide antiepileptic therapy. In our experience, rsfMRI complements conventional MR imaging and task-based fMRI for the evaluation of patients with seizure recurrence after laser ablation, and represents a potential noninvasive biomarker for functional connectivity.

Original languageEnglish (US)
Pages (from-to)156-160
Number of pages5
JournalEpilepsy Research
StatePublished - May 2018


  • Brain mapping
  • Functional connectivity
  • Independent component analysis
  • Pediatric epilepsy surgery
  • Resting-state functional MRI
  • Stereotactic laser ablation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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