Connectivity precedes function in the development of the visual word form area

Zeynep M. Saygin*, David E. Osher, Elizabeth S. Norton, Deanna A. Youssoufian, Sara D. Beach, Jenelle Feather, Nadine Gaab, John D.E. Gabrieli, Nancy Kanwisher

*Corresponding author for this work

Research output: Contribution to journalArticle

119 Scopus citations

Abstract

What determines the cortical location at which a given functionally specific region will arise in development? We tested the hypothesis that functionally specific regions develop in their characteristic locations because of pre-existing differences in the extrinsic connectivity of that region to the rest of the brain. We exploited the visual word form area (VWFA) as a test case, scanning children with diffusion and functional imaging at age 5, before they learned to read, and at age 8, after they learned to read. We found the VWFA developed functionally in this interval and that its location in a particular child at age 8 could be predicted from that child's connectivity fingerprints (but not functional responses) at age 5. These results suggest that early connectivity instructs the functional development of the VWFA, possibly reflecting a general mechanism of cortical development.

Original languageEnglish (US)
Pages (from-to)1250-1255
Number of pages6
JournalNature neuroscience
Volume19
Issue number9
DOIs
StatePublished - Sep 1 2016

ASJC Scopus subject areas

  • Neuroscience(all)

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