Connexins in the sinoatrial and atrioventricular nodes

M. R. Boyett*, S. Inada, S. Yoo, A. J. Li, J. Liu, J. Tellez, I. D. Greener, H. Honjo, R. Billeter, M. Lei, H. Zhang, I. R. Efimov, H. Dobrzynski

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

86 Scopus citations

Abstract

The sinoatrial node (SAN) and the atrioventricular node (AVN) are specialized tissues in the heart: the SAN is specialized for pacemaking (it is the pacemaker of the heart), whereas the AVN is specialized for slow conduction of the action potential (to introduce a delay between atrial and ventricular activation during the cardiac cycle). These functions have special requirements regarding electrical coupling and, therefore, expression of connexin isoforms. Electrical coupling in the center of the SAN should be weak to protect it from the inhibitory electrotonic influence of the more hyperpolarized non-pacemaking atrial muscle surrounding the SAN. However, for the SAN to be able to drive the atrial muscle, electrical coupling should be strong in the periphery of the SAN. Consistent with this, in the center of the SAN there is no expression of Cx43 (the principal connexin of the working myocardium) and little expression of Cx40, but there is expression of Cx45 and Cx30.2, whereas in the periphery of the SAN Cx43 as well Cx45 is expressed. In the AVN, there is a similar pattern of expression of connexins as in the center of the SAN and this is likely to be in large part responsible for the slow conduction of the action potential.

Original languageEnglish (US)
Title of host publicationCardiac Gap Junctions
EditorsStefan Dhein
Pages175-197
Number of pages23
DOIs
StatePublished - 2006

Publication series

NameAdvances in Cardiology
Volume42
ISSN (Print)0065-2326

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Boyett, M. R., Inada, S., Yoo, S., Li, A. J., Liu, J., Tellez, J., Greener, I. D., Honjo, H., Billeter, R., Lei, M., Zhang, H., Efimov, I. R., & Dobrzynski, H. (2006). Connexins in the sinoatrial and atrioventricular nodes. In S. Dhein (Ed.), Cardiac Gap Junctions (pp. 175-197). (Advances in Cardiology; Vol. 42). https://doi.org/10.1159/000092569