Consensus on DEfinition of Food Allergy SEverity (DEFASE): Protocol for a systematic review

Stefania Arasi*, Ulugbek Nurmatov, Paul J. Turner, Ignacio J. Ansotegui, Shahd Daher, Audrey Dunn-Galvin, Motohiro Ebisawa, Philippe Eigenmann, Montserrat Fernandez-Rivas, Ruchi Gupta, Anna Nowak-Wegrzyn, Stavros Petrou, Graham Roberts, Mario A. Sánchez Borges, Sayantani B. Sindher, Luciana Kase Tanno, Marta Vazquez-Ortiz, Brian P. Vickery, Gary Wing Kin Wong, Alessandro Fiocchi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Background and aims: The term “Food Allergy” refers to a complex global health problem with a wide spectrum of severity. However, a uniform definition of severe food allergy is currently missing. This systematic review is the preliminary step towards a state-of-the-art synopsis of the current evidence relating to the severity of IgE-mediated food allergy; it will inform attempts to develop a consensus to define food allergy severity by clinicians and other stakeholders. Methods: We will undertake a systematic review, which will involve searching international biomedical databases for published studies. Studies will be independently screened against pre-defined eligibility criteria and critically appraised by established instruments. Data will be descriptively and, if possible and applicable, quantitatively synthesised. Ethics and dissemination: This study does not require any specific ethical approval since it is a systematic review. We plan to report results from this systematic review in a peer reviewed journal. These results will be used to inform the development of an international consensus to define severe food allergy. Author's potential conflicts of interest are clearly stated. PROSPERO registration number: CRD42020183103.

Original languageEnglish (US)
Article number100493
JournalWorld Allergy Organization Journal
Issue number12
StatePublished - Dec 2020


  • Classification
  • Definition
  • Food allergy
  • Severity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine


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