Consensus on the management of intracranial germ-cell tumours

Matthew J. Murray, Ute Bartels, Ryo Nishikawa, Jason Fangusaro, Masao Matsutani, James C. Nicholson*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

83 Scopus citations


The management of intracranial germ-cell tumours is complex because of varied clinical presentations, tumour sites, treatments and outcomes, and the need for multidisciplinary input. Participants of the 2013 Third International CNS Germ Cell Tumour Symposium (Cambridge, UK) agreed to undertake a multidisciplinary Delphi process to identify consensus in the clinical management of intracranial germ-cell tumours. 77 delegates from the symposium were selected as suitable experts in the field and were invited to participate in the Delphi survey, of which 64 (83%) responded to the invitation. Invited participants represented multiple disciplines from Asia, Australasia, Europe, and the Americas. 38 consensus statements encompassing aspects of intracranial germ-cell tumour work-up, staging, treatment, and follow-up were prepared. To achieve consensus, statements required at least 70% agreement from at least 60% of respondents. Overall, 34 (89%) of 38 statements met consensus criteria. This international Delphi approach has defined key areas of consensus that will help guide and streamline clinical management of patients with intracranial germ-cell tumours. Additionally, the Delphi approach identified areas of different understanding and clinical practice internationally in the management of these tumours, areas which should be the focus of future collaborative studies. Such efforts should translate into improved patient outcomes.

Original languageEnglish (US)
Article number212
Pages (from-to)e470-e477
JournalThe Lancet Oncology
Issue number9
StatePublished - Sep 1 2015

ASJC Scopus subject areas

  • Oncology


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