Consensus on the role of human cytomegalovirus in glioblastoma

Kristine Dziurzynski*, Susan M. Chang, Amy B. Heimberger, Robert F. Kalejta, Stuart R.Mc Gregor Dallas, Martine Smit, Liliana Soroceanu, Charles S. Cobbs

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

228 Scopus citations

Abstract

The human cytomegalovirus (HCMV) and glioma symposium was convened on April 17, 2011 in Washington, DC, and was attended by oncologists and virologists involved in studying the relationship between HCMV and gliomas. The purpose of the meeting was to reach a consensus on the role of HCMV in the pathology of gliomas and to clarify directions for future research. First, the group summarized data that describe how HCMV biology overlaps with the key pathways of cancer. Then, on the basis of published data and ongoing research, a consensus was reached that there is sufficient evidence to conclude that HCMV sequences and viral gene expression exist in most, if not all, malignant gliomas, that HCMV could modulate the malignant phenotype in glioblastomas by interacting with key signaling pathways; and that HCMV could serve as a novel target for a variety of therapeutic strategies. In summary, existing evidence supports an oncomodulatory role for HCMV in malignant gliomas, but future studies need to focus on determining the role of HCMV as a glioma-initiating event.

Original languageEnglish (US)
Pages (from-to)246-255
Number of pages10
JournalNeuro-oncology
Volume14
Issue number3
DOIs
StatePublished - Mar 2012
Externally publishedYes

Keywords

  • DNA virus
  • cancer
  • gliomas
  • herpesvirus
  • human cytomegalovirus

ASJC Scopus subject areas

  • Clinical Neurology
  • Oncology
  • Cancer Research

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