Consequences of circadian disruption on cardiometabolic health

Sirimon Reutrakul, Kristen L. Knutson*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations


Cardiovascular disease, diabetes and obesity are highly prevalent diseases associated with reduced quality of life and life expectancy. We discuss a novel risk factor for these cardiometabolic diseases: circadian disruption. Circadian disruption occurs when the internal circadian (∼24-hour) rhythms are not in synchrony with the environment or each other. This paper reviews (1) cardiometabolic health of shift work, which often leads to circadian disruption, (2) effects of experimentally disrupted circadian rhythms on cardiometabolic function, (3) observational studies of sleep timing and behavioral chronotype, and (4) potential mediators linking chronotype and shift work to circadian disruption and cardiometabolic health.

Original languageEnglish (US)
Pages (from-to)455-468
Number of pages14
JournalSleep Medicine Clinics
Issue number4
StatePublished - Dec 2015


  • Cardiovascular disease
  • Circadian rhythms
  • Diabetes
  • Shift work

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

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