TY - JOUR
T1 - Conserved signaling pathways underlying heterotopic ossification
AU - Kan, Chen
AU - Chen, Lijun
AU - Hu, Yangyang
AU - Ding, Na
AU - Lu, Haimei
AU - Li, Yuyun
AU - Kessler, John A.
AU - Kan, Lixin
N1 - Funding Information:
We appreciate the help from many members of the Kessler lab. LK is supported in part by National Nature Science Foundation of China (81472087) and Nature Science Foundation of Anhui Province, China (1508085MC45).
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/4
Y1 - 2018/4
N2 - Heterotopic ossification (HO), a serious disorder of extra-skeletal bone formation, occurs as a common complication of trauma or in rare genetic disorders. Many conserved signaling pathways have been implicated in HO; however, the exact underlying molecular mechanisms for many forms of HO are still unclear. The emerging picture is that dysregulation of bone morphogenetic protein (BMP) signaling plays a central role in the process, but that other conserved signaling pathways, such as Hedgehog (HH), Wnt/β-catenin and Fibroblast growth factors (FGF), are also involved, either through cross-talk with BMP signaling or through other independent mechanisms. Deep understanding of the conserved signaling pathways is necessary for the effective prevention and treatment of HO. In this review, we update and integrate recent progress in this area. Hopefully, our discussion will point to novel promising, druggable loci for further translational research and successful clinical applications.
AB - Heterotopic ossification (HO), a serious disorder of extra-skeletal bone formation, occurs as a common complication of trauma or in rare genetic disorders. Many conserved signaling pathways have been implicated in HO; however, the exact underlying molecular mechanisms for many forms of HO are still unclear. The emerging picture is that dysregulation of bone morphogenetic protein (BMP) signaling plays a central role in the process, but that other conserved signaling pathways, such as Hedgehog (HH), Wnt/β-catenin and Fibroblast growth factors (FGF), are also involved, either through cross-talk with BMP signaling or through other independent mechanisms. Deep understanding of the conserved signaling pathways is necessary for the effective prevention and treatment of HO. In this review, we update and integrate recent progress in this area. Hopefully, our discussion will point to novel promising, druggable loci for further translational research and successful clinical applications.
KW - Bone morphogenetic protein (BMP)
KW - Conserved signaling pathways
KW - Fibroblast growth factor (FGF)
KW - Fibrodysplasia ossificans progressiva (FOP)
KW - Hedgehog (HH)
KW - Heterotopic ossification (HO)
KW - Transforming growth factor β (TGF-β)
KW - Wnt/β-catenin
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U2 - 10.1016/j.bone.2017.04.014
DO - 10.1016/j.bone.2017.04.014
M3 - Review article
C2 - 28455214
AN - SCOPUS:85018376821
SN - 8756-3282
VL - 109
SP - 43
EP - 48
JO - Bone
JF - Bone
ER -
