Contact Lens-induced Limbal Stem Cell Deficiency

Jennifer Rossen; Alec Amram; Behrad Milani; Dongwook Park; Jennifer Harthan; Charlotte Joslin; Timothy McMahon; Ali Djalilian

doi:10.1016/j.jtos.2016.06.003

Contact Lens-induced Limbal Stem Cell Deficiency

Jennifer Rossen, Alec Amram, Behrad Milani, Dongwook Park, Jennifer Harthan, Charlotte Joslin, Timothy McMahon, Ali Djalilian^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

Limbal stem cell deficiency (LSCD) is a pathologic condition caused by the dysfunction and/or destruction of stem cell precursors of the corneal epithelium, typified clinically by corneal conjunctivalization. The purpose of this review is to critically discuss a less well-known cause of limbal stem cell disease: contact lens (CL) wear. A literature search was conducted to include original articles containing patients with CL-induced LSCD. This review describes epidemiology, diagnostic strategies, pathogenesis, differential diagnosis, and treatment modalities for this condition.

Original language	English (US)
Pages (from-to)	419-434
Number of pages	16
Journal	Ocular Surface
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/j.jtos.2016.06.003
State	Published - Oct 1 2016
Externally published	Yes

Keywords

contact lens
corneal conjunctivalization
limbal stem cell deficiency
limbal stem cells

ASJC Scopus subject areas

Ophthalmology

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10.1016/j.jtos.2016.06.003

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title = "Contact Lens-induced Limbal Stem Cell Deficiency",

abstract = "Limbal stem cell deficiency (LSCD) is a pathologic condition caused by the dysfunction and/or destruction of stem cell precursors of the corneal epithelium, typified clinically by corneal conjunctivalization. The purpose of this review is to critically discuss a less well-known cause of limbal stem cell disease: contact lens (CL) wear. A literature search was conducted to include original articles containing patients with CL-induced LSCD. This review describes epidemiology, diagnostic strategies, pathogenesis, differential diagnosis, and treatment modalities for this condition.",

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author = "Jennifer Rossen and Alec Amram and Behrad Milani and Dongwook Park and Jennifer Harthan and Charlotte Joslin and Timothy McMahon and Ali Djalilian",

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T1 - Contact Lens-induced Limbal Stem Cell Deficiency

AU - Rossen, Jennifer

AU - Amram, Alec

AU - Milani, Behrad

AU - Park, Dongwook

AU - Harthan, Jennifer

AU - Joslin, Charlotte

AU - McMahon, Timothy

AU - Djalilian, Ali

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Limbal stem cell deficiency (LSCD) is a pathologic condition caused by the dysfunction and/or destruction of stem cell precursors of the corneal epithelium, typified clinically by corneal conjunctivalization. The purpose of this review is to critically discuss a less well-known cause of limbal stem cell disease: contact lens (CL) wear. A literature search was conducted to include original articles containing patients with CL-induced LSCD. This review describes epidemiology, diagnostic strategies, pathogenesis, differential diagnosis, and treatment modalities for this condition.

AB - Limbal stem cell deficiency (LSCD) is a pathologic condition caused by the dysfunction and/or destruction of stem cell precursors of the corneal epithelium, typified clinically by corneal conjunctivalization. The purpose of this review is to critically discuss a less well-known cause of limbal stem cell disease: contact lens (CL) wear. A literature search was conducted to include original articles containing patients with CL-induced LSCD. This review describes epidemiology, diagnostic strategies, pathogenesis, differential diagnosis, and treatment modalities for this condition.

KW - contact lens

KW - corneal conjunctivalization

KW - limbal stem cell deficiency

KW - limbal stem cells

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DO - 10.1016/j.jtos.2016.06.003

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AN - SCOPUS:84992361742

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EP - 434

JO - Ocular Surface

JF - Ocular Surface

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ER -

Contact Lens-induced Limbal Stem Cell Deficiency

Abstract

Keywords

ASJC Scopus subject areas

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