Contact Lens-induced Limbal Stem Cell Deficiency

Jennifer Rossen, Alec Amram, Behrad Milani, Dongwook Park, Jennifer Harthan, Charlotte Joslin, Timothy McMahon, Ali Djalilian*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


Limbal stem cell deficiency (LSCD) is a pathologic condition caused by the dysfunction and/or destruction of stem cell precursors of the corneal epithelium, typified clinically by corneal conjunctivalization. The purpose of this review is to critically discuss a less well-known cause of limbal stem cell disease: contact lens (CL) wear. A literature search was conducted to include original articles containing patients with CL-induced LSCD. This review describes epidemiology, diagnostic strategies, pathogenesis, differential diagnosis, and treatment modalities for this condition.

Original languageEnglish (US)
Pages (from-to)419-434
Number of pages16
JournalOcular Surface
Issue number4
StatePublished - Oct 1 2016
Externally publishedYes


  • contact lens
  • corneal conjunctivalization
  • limbal stem cell deficiency
  • limbal stem cells

ASJC Scopus subject areas

  • Ophthalmology


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