Contactless, programmable acoustofluidic manipulation of objects on water

Peiran Zhang, Chuyi Chen, Feng Guo, Julien Philippe, Yuyang Gu, Zhenhua Tian, Hunter Bachman, Liqiang Ren, Shujie Yang, Zhanwei Zhong, Po Hsun Huang, Nicholas Katsanis, Krishnendu Chakrabarty, Tony Jun Huang*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Contact-free manipulation of small objects (e.g., cells, tissues, and droplets) using acoustic waves eliminates physical contact with structures and undesired surface adsorption. Pioneering acoustic-based, contact-free manipulation techniques (e.g., acoustic levitation) enable programmable manipulation but are limited by evaporation, bulky transducers, and inefficient acoustic coupling in air. Herein, we report an acoustofluidic mechanism for the contactless manipulation of small objects on water. A hollow-square-shaped interdigital transducer (IDT) is fabricated on lithium niobate (LiNbO3), immersed in water and used as a sound source to generate acoustic waves and as a micropump to pump fluid in the ±x and ±y orthogonal directions. As a result, objects which float adjacent to the excited IDT can be pushed unidirectionally (horizontally) in ±x and ±y following the directed acoustic wave propagation. A fluidic processor was developed by patterning IDT units in a 6-by-6 array. We demonstrate contactless, programmable manipulation on water of oil droplets and zebrafish larvae. This acoustofluidic-based manipulation opens avenues for the contactless, programmable processing of materials and small biosamples.

Original languageEnglish (US)
Pages (from-to)3397-3404
Number of pages8
JournalLab on a Chip
Volume19
Issue number20
DOIs
StatePublished - Oct 21 2019
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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  • Cite this

    Zhang, P., Chen, C., Guo, F., Philippe, J., Gu, Y., Tian, Z., Bachman, H., Ren, L., Yang, S., Zhong, Z., Huang, P. H., Katsanis, N., Chakrabarty, K., & Huang, T. J. (2019). Contactless, programmable acoustofluidic manipulation of objects on water. Lab on a Chip, 19(20), 3397-3404. https://doi.org/10.1039/c9lc00465c