Contemporary Algorithm for the Management of Hepatocellular Carcinoma in 2021: The Northwestern Approach

Adam Swersky, Laura Kulik, Aparna Kalyan, Karen Grace, Juan Carlos Caicedo, Robert J. Lewandowski, Riad Salem*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a major cause of cancer-related morbidity and mortality around the world. Frequently, concurrent liver dysfunction and variations in tumor burden make it difficult to design effective and standardized treatment pathways. Contemporary treatment guidelines designed for an era of personalized medicine should consider these features in a more clinically meaningful way to improve outcomes for patients across the HCC spectrum. Given the heterogeneity of HCC, we propose a detailed clinical algorithm for selecting optimal treatment using an evidence-based and practical approach, incorporating liver function, tumor burden, the extent of disease, and ultimate treatment intent, with the goal of individualizing clinical decision making.

Original languageEnglish (US)
Pages (from-to)432-437
Number of pages6
JournalSeminars in Interventional Radiology
Issue number4
StatePublished - Oct 1 2021


  • downstaging
  • interventional radiology
  • radioembolization
  • survival
  • transplantation
  • yttrium-90

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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