TY - JOUR
T1 - Contemporary Algorithm for the Management of Hepatocellular Carcinoma in 2021
T2 - The Northwestern Approach
AU - Swersky, Adam
AU - Kulik, Laura
AU - Kalyan, Aparna
AU - Grace, Karen
AU - Caicedo, Juan Carlos
AU - Lewandowski, Robert J.
AU - Salem, Riad
N1 - Publisher Copyright:
© 2021 Thieme Medical Publishers, Inc.. All rights reserved.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a major cause of cancer-related morbidity and mortality around the world. Frequently, concurrent liver dysfunction and variations in tumor burden make it difficult to design effective and standardized treatment pathways. Contemporary treatment guidelines designed for an era of personalized medicine should consider these features in a more clinically meaningful way to improve outcomes for patients across the HCC spectrum. Given the heterogeneity of HCC, we propose a detailed clinical algorithm for selecting optimal treatment using an evidence-based and practical approach, incorporating liver function, tumor burden, the extent of disease, and ultimate treatment intent, with the goal of individualizing clinical decision making.
AB - Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a major cause of cancer-related morbidity and mortality around the world. Frequently, concurrent liver dysfunction and variations in tumor burden make it difficult to design effective and standardized treatment pathways. Contemporary treatment guidelines designed for an era of personalized medicine should consider these features in a more clinically meaningful way to improve outcomes for patients across the HCC spectrum. Given the heterogeneity of HCC, we propose a detailed clinical algorithm for selecting optimal treatment using an evidence-based and practical approach, incorporating liver function, tumor burden, the extent of disease, and ultimate treatment intent, with the goal of individualizing clinical decision making.
KW - downstaging
KW - interventional radiology
KW - radioembolization
KW - survival
KW - transplantation
KW - yttrium-90
UR - http://www.scopus.com/inward/record.url?scp=85116907807&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85116907807&partnerID=8YFLogxK
U2 - 10.1055/s-0041-1735528
DO - 10.1055/s-0041-1735528
M3 - Review article
C2 - 34629710
AN - SCOPUS:85116907807
SN - 0739-9529
VL - 38
SP - 432
EP - 437
JO - Seminars in Interventional Radiology
JF - Seminars in Interventional Radiology
IS - 4
ER -