Contemporary Risk of Surgery in Patients With Ulcerative Colitis and Crohn's Disease: A Meta-Analysis of Population-Based Cohorts

Lester Tsai, Christopher Ma, Parambir S. Dulai, Larry J. Prokop, Samuel Eisenstein, Sonia L. Ramamoorthy, Brian G. Feagan, Vipul Jairath, William J. Sandborn, Siddharth Singh*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Background & Aims: We conducted a systematic review with meta-analysis to estimate rates and trends of colectomy in patients with ulcerative colitis (UC), and of primary and re-resection in patients with Crohn's disease (CD), focusing on contemporary risks. Methods: Through a systematic review until September 3, 2019, we identified population-based cohort studies that reported patient-level cumulative risk of surgery in patients with UC and CD. We evaluated overall and contemporary risk (after 2000) of surgery and analyzed time trends through mixed-effects meta-regression. Results: In patients with UC (26 studies), the overall 1-, 5-, and 10-year risks of colectomy was 4.0% (95% CI, 3.3–5.0), 8.8% (95% CI, 7.7–10.0), and 13.3% (95% CI, 11.3–15.5), respectively, with a decrease in risk over time (P <.001). Corresponding contemporary risks were 2.8% (95% CI, 2.0–3.9), 7.0% (95% CI, 5.7–8.6), and 9.6% (95% CI, 6.3–14.2), respectively. In patients with CD (22 studies), the overall 1-, 5-, and 10-year risk of surgery was 18.7% (95% CI, 15.0–23.0), 28.0% (95% CI, 24.0–32.4), and 39.5% (95% CI, 33.3–46.2), respectively, with a decrease in risk over time (P <.001). Corresponding contemporary risks were 12.3% (95% CI, 10.8–14.0), 18.0% (95% CI, 15.4–21.0), and 26.2% (95% CI, 23.4–29.4), respectively. In a meta-analysis of 8 studies in patients with CD with prior resection, the cumulative risk of a second resection at 5 and 10 years after the first resection was 17.7% (95% CI, 13.5–22.9) and 31.3% (95% CI, 24.1–39.6), respectively. Conclusions: Patient-level risks of surgery have decreased significantly over time, with a 5-year cumulative risk of surgery of 7.0% in UC and 18.0% in CD in contemporary cohorts. This decrease may be related to early detection and/or better treatment.

Original languageEnglish (US)
Pages (from-to)2031-2045.e11
JournalClinical Gastroenterology and Hepatology
Volume19
Issue number10
DOIs
StatePublished - Oct 2021
Externally publishedYes

Keywords

  • Disease Modification
  • Inflammatory Bowel Diseases
  • Natural History
  • Resection
  • Tumor Necrosis Factor

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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