Context and explicit threat cue modulation of the startle reflex

Preliminary evidence of distinctions between adolescents with principal fear disorders versus distress disorders

Allison M. Waters, Maria Nazarian, Susan Mineka, Richard E Zinbarg, James W Griffith, Bruce Naliboff, Edward M. Ornitz, Michelle G. Craske*

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Anxiety and depression are prevalent, impairing disorders. High comorbidity has raised questions about how to define and classify them. Structural models emphasise distinctions between "fear" and "distress" disorders while other initiatives propose they be defined by neurobiological indicators that cut across disorders. This study examined startle reflex (SR) modulation in adolescents with principal fear disorders (specific phobia; social phobia) (n=20), distress disorders (unipolar depressive disorders, dysthymia, generalised anxiety disorder; post-traumatic stress disorder) (n=9), and controls (n=29) during (a) baseline conditions, (b) threat context conditions (presence of contraction pads over the biceps muscle), and (c) an explicit threat cue paradigm involving phases that signalled safety from aversive stimuli (early and late stages of safe phases; early stages of danger phases) and phases that signalled immediate danger of an aversive stimulus (late stages of danger phases). Adolescents with principal fear disorders showed larger SRs than other groups throughout safe phases and early stages of danger phases. SRs did not differ between groups during late danger phases. Adolescents with principal distress disorders showed attenuated SRs during baseline and context conditions compared to other groups. Preliminary findings support initiatives to redefine emotional disorders based on neurobiological functioning.

Original languageEnglish (US)
Pages (from-to)93-99
Number of pages7
JournalPsychiatry Research
Volume217
Issue number1-2
DOIs
StatePublished - Jun 30 2014

Fingerprint

Startle Reflex
Fear
Cues
Structural Models
Depressive Disorder
Post-Traumatic Stress Disorders
Anxiety Disorders
Comorbidity
Anxiety
Depression
Safety
Muscles

Keywords

  • Adolescents
  • Distress disorders
  • Fear disorders
  • Startle reflexes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

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Context and explicit threat cue modulation of the startle reflex : Preliminary evidence of distinctions between adolescents with principal fear disorders versus distress disorders. / Waters, Allison M.; Nazarian, Maria; Mineka, Susan; Zinbarg, Richard E; Griffith, James W; Naliboff, Bruce; Ornitz, Edward M.; Craske, Michelle G.

In: Psychiatry Research, Vol. 217, No. 1-2, 30.06.2014, p. 93-99.

Research output: Contribution to journalArticle

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AU - Waters, Allison M.

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AU - Griffith, James W

AU - Naliboff, Bruce

AU - Ornitz, Edward M.

AU - Craske, Michelle G.

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