Context-Dependent Glioblastoma–Macrophage/Microglia Symbiosis and Associated Mechanisms

Wenjing Xuan, Maciej S. Lesniak, Charles David James, Amy B. Heimberger, Peiwen Chen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Glioblastoma (GBM) is a lethal form of primary brain tumor in human adults. The impact of tumor-intrinsic alterations is not exclusively confined to cancer cells but can also be extended to the tumor microenvironment (TME). Glioblastoma-associated macrophages/microglia (GAMs) are a prominent type of immune cells that account for up to 50% of total cells in GBM. Emerging evidence suggests that context-dependent GBM–GAM symbiotic interactions are pivotal for tumor growth and progression. Here, we discuss how specific genetic alterations in GBM cells affect GAM biology and, reciprocally, how GAMs support GBM progression. We hypothesize that understanding context-dependent GBM–GAM symbiosis may reveal the molecular basis of GBM tumorigenesis and lead to novel candidate treatment approaches aiming to improve GBM patient outcomes.

Original languageEnglish (US)
Pages (from-to)280-292
Number of pages13
JournalTrends in Immunology
Volume42
Issue number4
DOIs
StatePublished - Apr 2021

Keywords

  • crosstalk
  • glioblastoma
  • heterogeneity
  • macrophages
  • microglia
  • symbiosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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