Context-dependent photodimerization in isolated thymine-thymine steps in DNA

Mahesh Hariharan, Frederick D. Lewis

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The effect of 280 nm irradiation on a family of synthetic DNA hairpins possessing an alkane linker connecting a six-base pair stem having a single T-T step located at different positions within the hairpin has been investigated. A single adduct assigned to the product of 2+2 dimerization is obtained except in the case of a T-T step located adjacent to the linker, in which case both 2+2 and 6-4 adducts are obtained. The efficiency of dimerization is similar for three hairpins having a T-T step located within the duplex interior. Lower efficiency is observed for a T-T step located at the open end of the hairpin and in T overhangs, whereas higher efficiency is observed for the T-T step adjacent to the linker and in a single T bulge. The context-dependence of dimerization efficiency is discussed.

Original languageEnglish (US)
Pages (from-to)11870-11871
Number of pages2
JournalJournal of the American Chemical Society
Issue number36
StatePublished - Sep 10 2008

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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