Context-dependent regulation of Wnt signaling through the primary cilium

Edwin C. Oh, Elias Nicholas Katsanis*

*Corresponding author for this work

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

The primary ciliumis a highly conserved environmental sensor andmodulator of fluid movement in tubular structures. The growing recognition of mutations among its many components has led to the discovery of new disorders collectively called ciliopathies. Ciliary dysfunction disturbs a variety of signaling pathways along its basal body and axoneme that are critical for embryonic development and cell and organ homeostasis. Among themany pathways, here we discuss the emerging role of Wnt proteins in morphogenic signaling and ciliary biology during health and disease.

Original languageEnglish (US)
Pages (from-to)10-18
Number of pages9
JournalJournal of the American Society of Nephrology
Volume24
Issue number1
DOIs
StatePublished - Dec 28 2013

ASJC Scopus subject areas

  • Nephrology

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