Contextual and Temporal Modulation of Extinction: Behavioral and Biological Mechanisms

Mark E. Bouton*, R. Frederick Westbrook, Kevin A. Corcoran, Stephen Maren

*Corresponding author for this work

Research output: Contribution to journalReview article

475 Scopus citations

Abstract

Extinction depends, at least partly, on new learning that is specific to the context in which it is learned. Several behavioral phenomena (renewal, reinstatement, spontaneous recovery, and rapid reacquisition) suggest the importance of context in extinction. The present article reviews research on the behavioral and neurobiological mechanisms of contextual influences on extinction learning and retrieval. Contexts appear to select or retrieve the current relationship of the conditional stimulus (CS) with the unconditional stimulus (US), and they are provided by physical background cues, interoceptive drug cues, emotions, recent trials, and the passage of time. The current article pays particular attention to the effects of recent trials and trial spacing. Control of fear extinction by physical context involves interactions between the dorsal hippocampus and the lateral nucleus of the amygdala. This interaction may be mediated by gamma-aminobutyric acid (GABA)-ergic and adrenergic mechanisms.

Original languageEnglish (US)
Pages (from-to)352-360
Number of pages9
JournalBiological psychiatry
Volume60
Issue number4
DOIs
StatePublished - Aug 15 2006

Keywords

  • Context
  • behavioral mechanisms
  • brain mechanisms
  • extinction

ASJC Scopus subject areas

  • Biological Psychiatry

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