Continuing Trends in the Prevalence of Right-Sided Lesions Among Colorectal Carcinomas

Blake Cady*, Michael D. Stone, Jeffrey Wayne

*Corresponding author for this work

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The shift of colorectal carcinoma location toward the proximal colon has been reported. This study documents that this statistically significant trend has continued through 1992. An increase in transverse and descending colon cancers is now apparent also. Only 59% of all large-bowel cancers occurred distal to the descending colon between 1978 and 1992. Both right-sided and distal large-bowel cancers have significantly decreased in size, yet the incidence and frequency of lymph node metastases have not changed over a 65-year interval (from 1928 to 1992). This constant proportion of lymph node metastases may suggest distinct biological subsets of cancers (lymph node avid vs lymph node avoidance). The progression from small size with fewer metastases to large size with more lymph node metastases occurs only in some of the smallest distal colorectal cancers.

Original languageEnglish (US)
Pages (from-to)505-509
Number of pages5
JournalArchives of Surgery
Volume128
Issue number5
DOIs
StatePublished - May 1993

Fingerprint

Colorectal Neoplasms
Lymph Nodes
Colonic Neoplasms
Neoplasm Metastasis
Descending Colon
Transverse Colon
Colon
Incidence
Neoplasms

ASJC Scopus subject areas

  • Surgery

Cite this

@article{1de3714596624d2598bb03e2bf6416c2,
title = "Continuing Trends in the Prevalence of Right-Sided Lesions Among Colorectal Carcinomas",
abstract = "The shift of colorectal carcinoma location toward the proximal colon has been reported. This study documents that this statistically significant trend has continued through 1992. An increase in transverse and descending colon cancers is now apparent also. Only 59{\%} of all large-bowel cancers occurred distal to the descending colon between 1978 and 1992. Both right-sided and distal large-bowel cancers have significantly decreased in size, yet the incidence and frequency of lymph node metastases have not changed over a 65-year interval (from 1928 to 1992). This constant proportion of lymph node metastases may suggest distinct biological subsets of cancers (lymph node avid vs lymph node avoidance). The progression from small size with fewer metastases to large size with more lymph node metastases occurs only in some of the smallest distal colorectal cancers.",
author = "Blake Cady and Stone, {Michael D.} and Jeffrey Wayne",
year = "1993",
month = "5",
doi = "10.1001/archsurg.1993.01420170035004",
language = "English (US)",
volume = "128",
pages = "505--509",
journal = "JAMA Surgery",
issn = "2168-6254",
publisher = "American Medical Association",
number = "5",

}

Continuing Trends in the Prevalence of Right-Sided Lesions Among Colorectal Carcinomas. / Cady, Blake; Stone, Michael D.; Wayne, Jeffrey.

In: Archives of Surgery, Vol. 128, No. 5, 05.1993, p. 505-509.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Continuing Trends in the Prevalence of Right-Sided Lesions Among Colorectal Carcinomas

AU - Cady, Blake

AU - Stone, Michael D.

AU - Wayne, Jeffrey

PY - 1993/5

Y1 - 1993/5

N2 - The shift of colorectal carcinoma location toward the proximal colon has been reported. This study documents that this statistically significant trend has continued through 1992. An increase in transverse and descending colon cancers is now apparent also. Only 59% of all large-bowel cancers occurred distal to the descending colon between 1978 and 1992. Both right-sided and distal large-bowel cancers have significantly decreased in size, yet the incidence and frequency of lymph node metastases have not changed over a 65-year interval (from 1928 to 1992). This constant proportion of lymph node metastases may suggest distinct biological subsets of cancers (lymph node avid vs lymph node avoidance). The progression from small size with fewer metastases to large size with more lymph node metastases occurs only in some of the smallest distal colorectal cancers.

AB - The shift of colorectal carcinoma location toward the proximal colon has been reported. This study documents that this statistically significant trend has continued through 1992. An increase in transverse and descending colon cancers is now apparent also. Only 59% of all large-bowel cancers occurred distal to the descending colon between 1978 and 1992. Both right-sided and distal large-bowel cancers have significantly decreased in size, yet the incidence and frequency of lymph node metastases have not changed over a 65-year interval (from 1928 to 1992). This constant proportion of lymph node metastases may suggest distinct biological subsets of cancers (lymph node avid vs lymph node avoidance). The progression from small size with fewer metastases to large size with more lymph node metastases occurs only in some of the smallest distal colorectal cancers.

UR - http://www.scopus.com/inward/record.url?scp=0027258730&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027258730&partnerID=8YFLogxK

U2 - 10.1001/archsurg.1993.01420170035004

DO - 10.1001/archsurg.1993.01420170035004

M3 - Article

C2 - 8489383

AN - SCOPUS:0027258730

VL - 128

SP - 505

EP - 509

JO - JAMA Surgery

JF - JAMA Surgery

SN - 2168-6254

IS - 5

ER -