Continuous enteral nutrition attenuates pulmonary edema in rats exposed to 100% oxygen

P. Factor*, K. Ridge, J. Alverdy, J. I. Sznajder

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Adult rats exposed to hyperoxia develop anorexia, weight loss, and a lung injury characterized by pulmonary edema and decreased lung liquid clearance. We hypothesized that maintenance of nutrition during hyperoxia could attenuate hyperoxiainduced pulmonary edema. To test this hypothesis, we enterally fed adult male Sprague-Dawley rats via gastrostomy tubes and exposed them to oxygen (inspired O2 fraction >0.95) for 64 h. In contrast to controls, enterally fed hyperoxic animals did not lose weight and had smaller pleural effusions and wet-to-dry weight ratios (a measure of lung edema) that were not different from room air controls. Enterally fed rats exposed to hyperoxia had increased levels of mRNA for the Na+-K+-ATPase α1- and β1-subunits and glutathione peroxidase. These findings suggest that maintenance of nutrition during an oxidative lung injury reduces lung edema, perhaps by allowing for continued expression and function of protective proteins such as the Na+-K+-ATPase.

Original languageEnglish (US)
Pages (from-to)1759-1765
Number of pages7
JournalJournal of applied physiology
Volume89
Issue number5
DOIs
StatePublished - 2000

Keywords

  • Glutathione peroxidase
  • Hyperoxia
  • Sodium-potassium-adenosine 5'-triphosphatase

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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