Continuous flow Overhauser dynamic nuclear polarization of water in the fringe field of a clinical magnetic resonance imaging system for authentic image contrast

Mark D. Lingwood; Ting Ann Siaw; Napapon Sailasuta; Brian D. Ross; Pratip Bhattacharya; Songi Han

doi:10.1016/j.jmr.2010.05.008

Continuous flow Overhauser dynamic nuclear polarization of water in the fringe field of a clinical magnetic resonance imaging system for authentic image contrast

Mark D. Lingwood, Ting Ann Siaw, Napapon Sailasuta, Brian D. Ross, Pratip Bhattacharya, Songi Han^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

We describe and demonstrate a system to generate hyperpolarized water in the 0.35 T fringe field of a clinical 1.5 T whole-body magnetic resonance imaging (MRI) magnet. Once generated, the hyperpolarized water is quickly and continuously transferred from the 0.35 T fringe to the 1.5 T center field of the same magnet for image acquisition using standard MRI equipment. The hyperpolarization is based on Overhauser dynamic nuclear polarization (DNP), which effectively and quickly transfers the higher spin polarization of free radicals to nuclear spins at ambient temperatures. We visualize the dispersion of hyperpolarized water as it flows through water-saturated systems by utilizing an observed-15-fold DNP signal enhancement with respect to the unenhanced ¹H MRI signal of water at 1.5 T. The experimental DNP apparatus presented here is readily portable and can be brought to and used with any conventional unshielded MRI system. A new method of immobilizing radicals to gel beads via polyelectrolyte linker arms is described, which led to superior flow Overhauser DNP performance compared to previously presented gels. We discuss the general applicability of Overhauser DNP of water and aqueous solutions in the fringe field of commercially available magnets with central fields up to 4.7 T.

Original language	English (US)
Pages (from-to)	247-254
Number of pages	8
Journal	Journal of Magnetic Resonance
Volume	205
Issue number	2
DOIs	https://doi.org/10.1016/j.jmr.2010.05.008
State	Published - 2010

Funding

This work was supported by the Faculty Early CAREER Award (20070057) of the National Science Foundation and the Packard Fellowship for Science and Engineering. BDR and PB thank NIH CA122513, NIH NS048589, NIH R21 CA118509 and TRDRP 16KT-0044 for research support. We thank Prof. Elliott Brown (UCSB ECE Department) for his help with the design of the microwave cavities, and Bruce Dunson and Terry Hart of the UCSB Chemistry Machine shop for their invaluable assistance with the construction of the microwave cavity and other components. We also thank Dr. Sam Tokoyama for his assistance and continued support of this project, and Dr. Peter Blümler for his involvement with the initial stages of these experiments.

Keywords

Angiography
DNP
Dynamic nuclear polarization
Flow imaging
Fringe field
Hyperpolarization
Hyperpolarized water
MRI
Magnetic resonance imaging
Overhauser effect
Polyvinylimidazole
RELIC
Time-of-flight imaging

ASJC Scopus subject areas

Condensed Matter Physics
Nuclear and High Energy Physics
Biophysics
Biochemistry

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10.1016/j.jmr.2010.05.008

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@article{02a855f9e598461aaf7bfa5e923fe857,

title = "Continuous flow Overhauser dynamic nuclear polarization of water in the fringe field of a clinical magnetic resonance imaging system for authentic image contrast",

abstract = "We describe and demonstrate a system to generate hyperpolarized water in the 0.35 T fringe field of a clinical 1.5 T whole-body magnetic resonance imaging (MRI) magnet. Once generated, the hyperpolarized water is quickly and continuously transferred from the 0.35 T fringe to the 1.5 T center field of the same magnet for image acquisition using standard MRI equipment. The hyperpolarization is based on Overhauser dynamic nuclear polarization (DNP), which effectively and quickly transfers the higher spin polarization of free radicals to nuclear spins at ambient temperatures. We visualize the dispersion of hyperpolarized water as it flows through water-saturated systems by utilizing an observed-15-fold DNP signal enhancement with respect to the unenhanced 1H MRI signal of water at 1.5 T. The experimental DNP apparatus presented here is readily portable and can be brought to and used with any conventional unshielded MRI system. A new method of immobilizing radicals to gel beads via polyelectrolyte linker arms is described, which led to superior flow Overhauser DNP performance compared to previously presented gels. We discuss the general applicability of Overhauser DNP of water and aqueous solutions in the fringe field of commercially available magnets with central fields up to 4.7 T.",

keywords = "Angiography, DNP, Dynamic nuclear polarization, Flow imaging, Fringe field, Hyperpolarization, Hyperpolarized water, MRI, Magnetic resonance imaging, Overhauser effect, Polyvinylimidazole, RELIC, Time-of-flight imaging",

author = "Lingwood, {Mark D.} and Siaw, {Ting Ann} and Napapon Sailasuta and Ross, {Brian D.} and Pratip Bhattacharya and Songi Han",

note = "Funding Information: This work was supported by the Faculty Early CAREER Award (20070057) of the National Science Foundation and the Packard Fellowship for Science and Engineering. BDR and PB thank NIH CA122513, NIH NS048589, NIH R21 CA118509 and TRDRP 16KT-0044 for research support. We thank Prof. Elliott Brown (UCSB ECE Department) for his help with the design of the microwave cavities, and Bruce Dunson and Terry Hart of the UCSB Chemistry Machine shop for their invaluable assistance with the construction of the microwave cavity and other components. We also thank Dr. Sam Tokoyama for his assistance and continued support of this project, and Dr. Peter Bl{\"u}mler for his involvement with the initial stages of these experiments.",

year = "2010",

doi = "10.1016/j.jmr.2010.05.008",

language = "English (US)",

volume = "205",

pages = "247--254",

journal = "Journal of Magnetic Resonance",

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T1 - Continuous flow Overhauser dynamic nuclear polarization of water in the fringe field of a clinical magnetic resonance imaging system for authentic image contrast

AU - Lingwood, Mark D.

AU - Siaw, Ting Ann

AU - Sailasuta, Napapon

AU - Ross, Brian D.

AU - Bhattacharya, Pratip

AU - Han, Songi

N1 - Funding Information: This work was supported by the Faculty Early CAREER Award (20070057) of the National Science Foundation and the Packard Fellowship for Science and Engineering. BDR and PB thank NIH CA122513, NIH NS048589, NIH R21 CA118509 and TRDRP 16KT-0044 for research support. We thank Prof. Elliott Brown (UCSB ECE Department) for his help with the design of the microwave cavities, and Bruce Dunson and Terry Hart of the UCSB Chemistry Machine shop for their invaluable assistance with the construction of the microwave cavity and other components. We also thank Dr. Sam Tokoyama for his assistance and continued support of this project, and Dr. Peter Blümler for his involvement with the initial stages of these experiments.

PY - 2010

Y1 - 2010

N2 - We describe and demonstrate a system to generate hyperpolarized water in the 0.35 T fringe field of a clinical 1.5 T whole-body magnetic resonance imaging (MRI) magnet. Once generated, the hyperpolarized water is quickly and continuously transferred from the 0.35 T fringe to the 1.5 T center field of the same magnet for image acquisition using standard MRI equipment. The hyperpolarization is based on Overhauser dynamic nuclear polarization (DNP), which effectively and quickly transfers the higher spin polarization of free radicals to nuclear spins at ambient temperatures. We visualize the dispersion of hyperpolarized water as it flows through water-saturated systems by utilizing an observed-15-fold DNP signal enhancement with respect to the unenhanced 1H MRI signal of water at 1.5 T. The experimental DNP apparatus presented here is readily portable and can be brought to and used with any conventional unshielded MRI system. A new method of immobilizing radicals to gel beads via polyelectrolyte linker arms is described, which led to superior flow Overhauser DNP performance compared to previously presented gels. We discuss the general applicability of Overhauser DNP of water and aqueous solutions in the fringe field of commercially available magnets with central fields up to 4.7 T.

AB - We describe and demonstrate a system to generate hyperpolarized water in the 0.35 T fringe field of a clinical 1.5 T whole-body magnetic resonance imaging (MRI) magnet. Once generated, the hyperpolarized water is quickly and continuously transferred from the 0.35 T fringe to the 1.5 T center field of the same magnet for image acquisition using standard MRI equipment. The hyperpolarization is based on Overhauser dynamic nuclear polarization (DNP), which effectively and quickly transfers the higher spin polarization of free radicals to nuclear spins at ambient temperatures. We visualize the dispersion of hyperpolarized water as it flows through water-saturated systems by utilizing an observed-15-fold DNP signal enhancement with respect to the unenhanced 1H MRI signal of water at 1.5 T. The experimental DNP apparatus presented here is readily portable and can be brought to and used with any conventional unshielded MRI system. A new method of immobilizing radicals to gel beads via polyelectrolyte linker arms is described, which led to superior flow Overhauser DNP performance compared to previously presented gels. We discuss the general applicability of Overhauser DNP of water and aqueous solutions in the fringe field of commercially available magnets with central fields up to 4.7 T.

KW - Angiography

KW - DNP

KW - Dynamic nuclear polarization

KW - Flow imaging

KW - Fringe field

KW - Hyperpolarization

KW - Hyperpolarized water

KW - MRI

KW - Magnetic resonance imaging

KW - Overhauser effect

KW - Polyvinylimidazole

KW - RELIC

KW - Time-of-flight imaging

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SN - 1090-7807

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EP - 254

JO - Journal of Magnetic Resonance

JF - Journal of Magnetic Resonance

IS - 2

ER -

Continuous flow Overhauser dynamic nuclear polarization of water in the fringe field of a clinical magnetic resonance imaging system for authentic image contrast

Abstract

Funding

Keywords

ASJC Scopus subject areas

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