Continuous sensing of blood by dark-field microscopy and surface-enhanced Raman spectroscopy

Anne Isabelle Henry*, B. Sharma, Richard P Van Duyne

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

Surface-enhanced Raman spectroscopy (SERS) is a rapid, label-free technique with multiplexing capabilities, making it very relevant for the sensitive real-time detection for biomedical applications. We have integrated SERS-active nanoparticles (nanotags) with a microfluidic device for the future detection of biomarkers in blood. We have developed a SERS imaging set-up in order to detect the SERS signal from multiple nanotags at the same time. We also imaged the nanotags by dark-field Rayleigh scattering, and were able to locate those particles in human blood. Finally, we probe the SERS signal of nanotags dispersed in optically clear solution (methanol) and human blood. No significant difference in the SERS intensity was observed.

Original languageEnglish (US)
Title of host publicationTechnical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012
Pages40-43
Number of pages4
StatePublished - Aug 20 2012
EventNanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012 - Santa Clara, CA, United States
Duration: Jun 18 2012Jun 21 2012

Other

OtherNanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012
CountryUnited States
CitySanta Clara, CA
Period6/18/126/21/12

Keywords

  • Biosensing
  • Diagnostics
  • Imaging
  • Nanoparticles
  • Surface-enhanced Raman spectroscopy

ASJC Scopus subject areas

  • Ceramics and Composites
  • Surfaces, Coatings and Films

Fingerprint Dive into the research topics of 'Continuous sensing of blood by dark-field microscopy and surface-enhanced Raman spectroscopy'. Together they form a unique fingerprint.

Cite this